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首页> 外文期刊>Psychiatry Research. Neuroimaging >Anterior cingulate cortex gray matter abnormalities in adults with attention deficit hyperactivity disorder: A voxel-based morphometry study
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Anterior cingulate cortex gray matter abnormalities in adults with attention deficit hyperactivity disorder: A voxel-based morphometry study

机译：成人注意力缺陷多动障碍的前扣带回皮层灰质异常：基于体素的形态学研究

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摘要

Attention deficit hyperactivity disorder (ADHD) is a psychiatric disease that affects children and persists in 50% of cases into adulthood. Magnetic Resonance Imaging (MRI) studies in children suggest that ADHD is associated with structural abnormalities in the brain. However, very little research has been carried out on adult ADHD. Using high-resolution MRI, we tested the hypothesis that adult ADHD patients exhibit gray and/ or white matter volume (GMV, WMV) abnormalities in the prefrontal cortex (PFC), cingulate cortex (CC), hippocampus and amygdala, also evaluating putative associations between volumetric data and symptoms of ADHD. We investigated 20 adult patients with ADHD and 20 age-matched healthy controls. We found significantly smaller GMV in the right and left anterior cingulate cortex (ACC) but no GMV/WMV difference in the PFC, hippocampus and amygdala. No correlation was found between ADHD behavioral measures and MRI data. Our results might suggest that adults with ADHD exhibit smaller GMV in the ACC, as measured by VBM. Volumetric abnormalities in the brain of adult ADHD patients might be less pronounced than those found in children and adolescents, although the role played by chronic stimulant treatment needs further investigation.
机译：注意缺陷多动障碍（ADHD）是一种精神疾病，会影响儿童，并在50％的成年人中持续存在。儿童磁共振成像（MRI）研究表明，ADHD与大脑结构异常有关。但是，关于成人多动症的研究很少。我们使用高分辨率MRI检验了以下假设：成年多动症患者在前额叶皮层（PFC），扣带回皮层（CC），海马和杏仁核中均表现出灰质和/或白质体积（GMV，WMV）异常，还评估了推定的联想体积数据和多动症的症状之间。我们调查了20位患有ADHD的成年患者和20位年龄相匹配的健康对照。我们发现左右前扣带回皮质（ACC）中的GMV明显较小，但PFC，海马和杏仁核中的GMV / WMV没有差异。在多动症行为指标和MRI数据之间未发现相关性。我们的结果可能表明，通过VBM测量，患有ADHD的成年人在ACC中的GMV较小。尽管慢性兴奋剂治疗所起的作用有待进一步研究，但成人ADHD患者大脑中的体积异常可能不如儿童和青少年明显。

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