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首页> 外文期刊>Psychiatry Research. Neuroimaging >Mindfulness practice leads to increases in regional brain gray matter density
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Mindfulness practice leads to increases in regional brain gray matter density

机译：正念练习导致区域脑灰质密度增加

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摘要

Therapeutic interventions that incorporate training in mindfulness meditation have become increasingly popular, but to date little is known about neural mechanisms associated with these interventions. Mindfulness-Based Stress Reduction (MBSR), one of the most widely used mindfulness training programs, has been reported to produce positive effects on psychological well-being and to ameliorate symptoms of a number of disorders. Here, we report a controlled longitudinal study to investigate pre-post changes in brain gray matter concentration attributable to participation in an MBSR program. Anatomical magnetic resonance (MR) images from 16 healthy, meditation-naive participants were obtained before and after they underwent the 8-week program. Changes in gray matter concentration were investigated using voxel-based morphometry, and compared with a waiting list control group of 17 individuals. Analyses in a priori regions of interest confirmed increases in gray matter concentration within the left hippocampus. Whole brain analyses identified increases in the posterior cingulate cortex, the temporo-parietal junction, and the cerebellum in the MBSR group compared with the controls. The results suggest that participation in MBSR is associated with changes in gray matter concentration in brain regions involved in learning and memory processes, emotion regulation, self-referential processing, and perspective taking.
机译：将训练纳入正念冥想的治疗性干预已变得越来越流行，但是迄今为止，与这些干预相关的神经机制知之甚少。基于正念减压（MBSR）是最广泛使用的正念训练计划之一，据报道对心理健康产生积极影响并改善许多疾病的症状。在这里，我们报告了一项受控的纵向研究，以调查可归因于MBSR计划参与的脑灰质浓度的前后变化。在进行为期8周的计划之前和之后，均从16位健康，天真的冥想参与者中获得了解剖磁共振（MR）图像。使用基于体素的形态计量学研究了灰质浓度的变化，并将其与17个人的等候名单对照组进行比较。在感兴趣的先验区域中的分析证实了左海马内灰质浓度的增加。全脑分析发现，与对照组相比，MBSR组的扣带回后叶，颞顶顶连接和小脑增加。结果表明，参与MBSR与大脑区域中涉及学习和记忆过程，情绪调节，自我参照过程和观点采择的灰质浓度变化有关。

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