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首页> 外文期刊>Psychiatry Research. Neuroimaging >Improvement of cognitive flexibility and cingulate blood flow correlates after atypical antipsychotic treatment in drug-naive patients with first-episode schizophrenia
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Improvement of cognitive flexibility and cingulate blood flow correlates after atypical antipsychotic treatment in drug-naive patients with first-episode schizophrenia

机译：非药物性初发精神分裂症患者非典型抗精神病药物治疗后认知灵活性的改善和扣带回血流相关

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The aim of this study was to examine the changes in cognitive flexibility and associated cerebral blood flow in the anterior cingulate lobe of drug-naive patients with first-episode schizophrenia who were treated with atypical antipsychotics for 6. weeks. Single photon emission computed tomography (SPECT) images were obtained from 8 healthy subjects both at rest and while performing the flexibility subtest of the TAP (Test for Attentional Performance). SPECT images were obtained in parallel from 8 first-episode drug-naive schizophrenic patients while they were performing the same task both before and after 6. weeks of neuroleptic treatment. In the control group, an increase in the perfusion indices of the dorsal section of the anterior cingulate gyrus was observed in the activation condition. Task performance was altered and the level of perfusion of the brain region related to the task execution was significantly decreased in the patients at baseline. After treatment, there was a significant improvement in both task performance and the level of perfusion of the dorsal section of the anterior cingulate. We conclude that treatment with second-generation neuroleptics improves cognitive flexibility, and there was a relationship between such improvements and normalization of perfusion indices of the involved brain areas.
机译：这项研究的目的是检查未接受过抗精神病药治疗的首发精神分裂症的初治药物初治患者的前扣带叶认知能力和相关脑血流的变化，这些患者接受了非典型的抗精神病药物治疗，持续了6周。从8名健康受试者的静止和进行TAP的柔韧性子测试（注意力表现测试）中获得了单光子发射计算机断层扫描（SPECT）图像。从8名首次发作的初次使用药物的精神分裂症患者同时在精神安定治疗前后6周内执行相同的任务，同时获得SPECT图像。在对照组中，在激活状态下观察到前扣带回背部的灌注指数增加。在基线时，患者的任务表现发生了变化，与任务执行相关的大脑区域的灌注水平明显降低。治疗后，任务表现和前扣带回背部分的灌注水平均有显着改善。我们得出的结论是，使用第二代抗精神病药可以改善认知灵活性，并且此类改善与受累脑区域的灌注指数正常化之间存在关系。

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