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首页> 外文期刊>Psychiatry Research. Neuroimaging >Comprehensive segmentation of subcortical brain volumes in early onset schizophrenia reveals limited structural abnormalities
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Comprehensive segmentation of subcortical brain volumes in early onset schizophrenia reveals limited structural abnormalities

机译：早发性精神分裂症的皮质下大脑容量的全面细分显示有限的结构异常

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Structural brain abnormalities are well documented in adult schizophrenia, but there are few studies of brain structures in early onset schizophrenia (EOS) and findings are inconsistent. Most previous EOS studies have been limited to global morphometric measures, such as whole gray matter (GM) or cerebrospinal fluid (CSF), or to single brain structures. The purpose of this study was to compare specific volumes and hemispheric lateralization in a large number of subcortical brain structures, between EOS patients and a healthy control group. High-resolution structural magnetic resonance images (MRI) and automatic brain volume segmentation were performed on 18 EOS patients and 33 healthy controls (11-18. years). A total of 29 brain structures were studied. The patients showed marked bilateral enlargements of the lateral ventricles and of the fourth ventricle, and bilateral enlargement of the caudate nuclei compared to the controls. For all other subcortical brain structures, there were no significant differences between the EOS group and the healthy control group, contrary to findings from the majority of morphometric studies of childhood or adult onset schizophrenia.
机译：在成人精神分裂症中有很好的脑结构异常记录，但是在早期发作的精神分裂症（EOS）中对脑结构的研究很少，并且发现也不一致。以前的大多数EOS研究都局限于整体形态学测量，例如全灰质（GM）或脑脊髓液（CSF），或单个大脑结构。这项研究的目的是比较EOS患者和健康对照组之间在大量皮层下大脑结构中的特定体积和半球偏侧化。对18例EOS患者和33例健康对照（11-18岁）进行了高分辨率结构磁共振图像（MRI）和自动脑体积分割。共研究了29种大脑结构。与对照组相比，患者表现出侧脑室和第四脑室的明显双侧增大，以及尾状核的双侧增大。对于其他所有皮质下大脑结构，EOS组与健康对照组之间没有显着差异，这与大多数儿童期或成人期精神分裂症的形态计量学研究结果相反。

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