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首页> 外文期刊>Psychiatry Research. Neuroimaging >Neuroimaging of hippocampal atrophy in early recognition of Alzheimer's disease - a critical appraisal after two decades of research
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Neuroimaging of hippocampal atrophy in early recognition of Alzheimer's disease - a critical appraisal after two decades of research

机译：海马萎缩的神经影像学可以早期识别阿尔茨海默氏病-经过二十多年的研究，这是一项至关重要的评估

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As a characteristic feature of Alzheimer's disease (AD) hippocampal atrophy (HA) can be demonstrated in the majority of patients by using neuroimaging techniques in particular magnetic resonance imaging (MRI). Hippocampal atrophy is associated with declarative memory deficits and can also be associated with changes of adjacent medial temporal substructures such as the parahippocampal gyms or the the entorhinal cortex. Similar findings are present in patients with mild cognitive impairment (MCI) albeit to a lesser extent. While these finding facilitate the diagnostic process in patients with clinical suspicious AD, the metric properties of hippocampal atrophy for delineating healthy aging from MCI and mild AD still appear to be rather limited; as such it is not sufficient to establish the diagnosis of AD (and even more so of MCI). This limitation partly refers to methodological issues and partly to the fact that hippocampal tissue integrity is subject to various pathogenetic influences other than AD. Moreover,the effects of hippocampal atrophy on the behavioral level (e.g. cognitive deficits) are modulated by the individual's cognitive reserve. From a clinical standpoint these observations are in line with the hypothesis that the onset and course of AD is influenced by a number of peristatic factors which are partly conceptualized in the concepts of brain and/or cognitive reserve. These complex interactions have to be considered when using the presence of hippocampal atrophy in the routine diagnostic procedure of AD. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
机译：作为阿尔茨海默氏病（AD）的特征，可以通过使用神经影像技术，尤其是磁共振成像（MRI）在大多数患者中证明海马萎缩（HA）。海马萎缩与声明性记忆缺陷有关，也可能与邻近的内侧颞亚结构（如海马旁体育馆或内嗅皮层）的变化有关。在轻度认知障碍（MCI）患者中也存在类似的发现，尽管程度较小。尽管这些发现促进了临床可疑AD患者的诊断过程，但海马萎缩用于区分MCI和轻度AD的健康衰老的度量标准似乎仍然很有限。因此，仅对AD（甚至MCI的诊断）进行诊断是不够的。这种局限性部分涉及方法学问题，部分涉及海马组织完整性受到除AD以外的各种致病影响的事实。而且，海马萎缩对行为水平（例如认知缺陷）的影响由个体的认知储备调节。从临床的观点来看，这些观察结果与假说的发生相一致，假说是AD的发作和病程受到许多围生因素的影响，这些因素在大脑和/或认知储备的概念中部分被概念化。当在AD的常规诊断程序中使用海马萎缩时，必须考虑这些复杂的相互作用。 （C）2015 Elsevier Ireland Ltd.保留所有权利。

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