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首页> 外文期刊>Psychiatry Research. Neuroimaging >Increased white matter connectivity in traumatized children with attention deficit hyperactivity disorder
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Increased white matter connectivity in traumatized children with attention deficit hyperactivity disorder

机译：患有注意力缺陷多动障碍的受创伤儿童的白质连通性增加

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To distinguish between the consequences of trauma exposure and those of attention deficit hyperactivity disorder (ADHD), we compared brain diffusion tensor imaging (DTI) of children according to the diagnosis and the presence of a potentially traumatic event (PTE). The Early Trauma Inventory Self ReportShort Form (ETISR-SF) was used for the assessment of PTEs. Subjects who experienced any traumatic event were placed in the PTE group, and subjects who did not experience such a traumatic event were placed in the non-PTE group. We examined the interactions between ADHD and PTEs in brain [fractional anisotropy (FA) values and mean diffusivity (MD) values] in 54 children with ADHD (29 with PTEs and 25 without PTEs) and 41 controls (18 with PTEs and 23 without PTEs). Analysis of covariance (ANCOVA) revealed main effects of ADHD for FA and MD values in several white matter tracts in the absence of main effects for PTEs. In addition, there was a significant ADHD-PTEs interaction in relation to FA and MD values in several white matter tracts. Further longitudinal studies in a larger sample are warranted to evaluate the neurobiological sequelae related to childhood trauma, ADHD, and interaction between the two. (C) 2015 Published by Elsevier Ireland Ltd.
机译：为了区分创伤暴露的后果和注意力缺陷多动障碍（ADHD）的后果，我们根据诊断和潜在创伤事件（PTE）的存在对儿童的脑扩散张量成像（DTI）进行了比较。早期创伤库存自我报告简表（ETISR-SF）用于评估PTE。经历过任何创伤事件的受试者被置于PTE组，而未经历过这种创伤事件的受试者被置于非PTE组。我们检查了54名ADHD儿童（29名有PTE和25名无PTE）和41名对照者（18名有PTE和23名无PTE）在大脑中的ADHD与PTE之间的相互作用[分数各向异性（FA）值和平均扩散率（MD）值] ）。协方差分析（ANCOVA）显示了ADHD对几个白质区中FA和MD值的主要影响，而对PTE没有主要影响。此外，在几个白质道中，ADHD-PTE与FA和MD值之间存在显着相互作用。有必要在较大的样本中进行进一步的纵向研究，以评估与儿童期创伤，多动症和两者之间的相互作用有关的神经生物学后遗症。 （C）2015由爱思唯尔爱尔兰有限公司出版。

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