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Impact of family history and depression on amygdala volume

机译：家族史和抑郁症对杏仁核体积的影响

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Family history of depression significantly impacts life-long depression risk. Family history could impact the stress and emotion regulation system that involves the amygdala. This study's purpose was to investigate family history's effect on amygdala volumes, and differences in first degree relatives with and without major depressive disorder (MDD). Participants, aged 18-65, were healthy volunteers (N= 52) with (n= 26) and without (n= 26) first degree family history, and patients with MDD (N= 48) with (n= 27) and without (n= 21)first-degree family history recruited for structural magnetic resonance imaging (MRI). Participants underwent clinical assessment followed by manual amygdala tracing. Patients with MDD without family history showed significantly larger right amygdala without a family history of MDD. These effects had larger right amygdala than healthy controls without MDD family history. These effects were pronounced in females. Family history and gender impacted amygdala volumes in all participants, providing a rationale for the inconsistent results in MDD amygdala studies. Higher familial risk in depression seems to be associated with smaller amygdala volumes, whereas depression alone is associated with larger amygdala volumes. Ultimately, these findings highlight consideration of family history and gender in research and treatment strategies.
机译：抑郁症的家族史显着影响终身抑郁症的风险。家族史可能影响涉及杏仁核的压力和情绪调节系统。这项研究的目的是调查家族史对杏仁核体积的影响，以及有或没有重大抑郁症（MDD）的一级亲属的差异。年龄在18-65岁之间的参与者是健康志愿者（N = 52），有（n = 26），没有（n = 26）一级家族史，有MDD（N = 48），有（n = 27），没有（n = 21）招募了一级家族史用于结构磁共振成像（MRI）。参加者进行了临床评估，随后进行了手工杏仁核追踪。没有家族史的MDD患者显示没有家族MDD的右杏仁核明显变大。与没有MDD家族史的健康对照相比，这些作用具有更大的右杏仁核。这些作用在女性中明显。家族史和性别影响了所有参与者的杏仁核体积，为MDD杏仁核研究结果不一致提供了理论依据。抑郁症中较高的家族风险似乎与杏仁核体积较小有关，而仅抑郁症与杏仁核体积较大相关。最终，这些发现突出了研究和治疗策略中对家族史和性别的考虑。

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