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首页> 外文期刊>Psycho-Oncology: Journal of the Psychological Social and Behavioral Dimensions of Cancer >Reach out to ENhancE Wellness in Older Cancer Survivors (RENEW): design, methods and recruitment challenges of a home-based exercise and diet intervention to improve physical function among long-term survivors of breast, prostate, and colorectal canc
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Reach out to ENhancE Wellness in Older Cancer Survivors (RENEW): design, methods and recruitment challenges of a home-based exercise and diet intervention to improve physical function among long-term survivors of breast, prostate, and colorectal canc

机译：增强老年癌症幸存者的健康（RENEW）：家庭锻炼和饮食干预的设计，方法和招募挑战，以改善长期乳腺癌，前列腺癌和结直肠癌幸存者的身体功能

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OBJECTIVE: Cure rates for cancer are increasing, especially for breast, prostate, and colorectal cancer. Despite positive trends in survivorship, a cancer diagnosis can trigger accelerated functional decline that can threaten independence, reduce quality-of-life and increase healthcare costs, especially among the elderly who comprise the majority of survivors. Lifestyle interventions may hold promise in reorienting functional decline in older cancer survivors, but few studies have been conducted. METHODS: We describe the design and methods of a randomized controlled trial, RENEW (Reach out to ENhancE Wellness), that tests whether a home-based multi-behavior intervention focused on exercise, and including a low saturated fat, plant-based diet, would improve physical functioning among 641 older, long-term (>or=5 years post-diagnosis) survivors of breast, prostate, or colorectal cancer. Challenges to recruitment are examined. RESULTS: Twenty thousand and fifteen cases were approached, and screened using atwo-step screening process to assure eligibility. This population of long-term, elderly cancer survivors had lower rates of response (approximately 11%) and higher rates of ineligibility (approximately 70%) than our previous intervention studies conducted on adults with newly diagnosed cancer. Significantly higher response rates were noted among survivors who were White, younger, and more proximal to diagnosis and breast cancer survivors (p-values<0.001). CONCLUSION: Older cancer survivors represent a vulnerable population for whom lifestyle interventions may hold promise. RENEW may provide guidance in allocating limited resources in order to maximize recruitment efforts aimed at this needy, but hard-to-reach population.
机译：目的：癌症的治愈率正在增加，尤其是乳腺癌，前列腺癌和结肠直肠癌。尽管幸存者呈积极趋势，但癌症诊断仍会触发功能加速下降，从而威胁独立性，降低生活质量并增加医疗保健成本，尤其是在占幸存者最多的老年人中。生活方式干预可能有望重新定位老年癌症幸存者的功能衰退，但很少进行研究。方法：我们描述了一项随机对照试验RENEW（提高健康水平）的设计和方法，该试验用于测试以家庭为基础的多行为干预措施是否侧重于运动，并包括低饱和脂肪，植物性饮食，会改善641名年龄较大，长期（诊断后≥5年）的乳腺癌，前列腺癌或大肠癌幸存者的身体机能。研究了招聘方面的挑战。结果：共筛选了2万5千5例病例，并通过两步筛选过程进行筛选，以确保符合条件。与我们先前对新诊断出的癌症的成年人进行的干预研究相比，这种长期的，老年的癌症幸存者的反应率较低（约11％），不合格率较高（约70％）。白人，年轻，更接近诊断的幸存者和乳腺癌幸存者的应答率明显更高（p值<0.001）。结论：老年癌症幸存者代表了一个脆弱的人群，生活方式干预可能会为他们带来希望。 RENEW可以为分配有限的资源提供指导，以最大程度地针对这一有需要但难以到达的人群进行招聘。

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