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Symptotic detection of chimerism:Y does it matter?

机译：嵌合体的症状检测：是吗？

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摘要

Microchimerism (MC), transplacental acquisition of allogeneic cells from the mother (maternofetal MC) or from the fetus (fetomaternal MC) has been in the focus of research recently. Amplicons using Y-chromosome specific SRY and DYS14 sequences have been used as markers to trace cells from a male fetus in the mother. The sensitivity of these markers in formaldehyde fixed paraffin embedded samples, however, is less than optimal. To study chimerism in breast cancer we took advantage of the evolutionaryhistory of the Y chromosome and designed amplicons on gene repeats to generate additive PCR signals. The increased sensitivity detected high incidence of male chimerism in normal breast tissues. We also showed correlation with protection from cancer withunique quantitative biology. Accumulating data from biology and medicine indicate that natural chimerism is astonishingly frequent and may affect human conditions. We hypothesize that it has significant evolutionary ramifications as well.
机译：微嵌合体（MC），从母亲（胎胎MC）或胎儿（胎儿母体MC）经胎盘获取同种异体细胞已成为最近研究的重点。使用Y染色体特异性SRY和DYS14序列的扩增子已用作标记来追踪母亲中男性胎儿的细胞。但是，这些标记物在甲醛固定的石蜡包埋样品中的灵敏度并非最佳。为了研究乳腺癌中的嵌合现象，我们利用了Y染色体的进化历史，并设计了基因重复序列上的扩增子以产生加性PCR信号。敏感性的提高检测到正常乳腺组织中男性嵌合症的发生率很高。我们还通过独特的定量生物学方法显示了与癌症防护的相关性。来自生物学和医学领域的不断积累的数据表明，自然嵌合现象异常频繁，并可能影响人类状况。我们假设它也具有重要的进化分支。

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