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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >The relationship of mood, endocrine, and sexual disorders in human immunodeficiency virus positive (HIV+) women: an exploratory study.
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The relationship of mood, endocrine, and sexual disorders in human immunodeficiency virus positive (HIV+) women: an exploratory study.

机译：人类免疫缺陷病毒阳性（HIV +）妇女的情绪，内分泌和性障碍的关系：一项探索性研究。

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OBJECTIVE: This exploratory study assessed the prevalence of mood disorders, sexual disorders, and endocrine abnormalities, and explored the relationship between these parameters in a sample of HIV+ women. METHOD: Fifty-four HIV+ women were evaluated with the Structured Clinical Interview for DSM-III-R (SCID) and measures of psychiatric symptom severity, psychological well-being, and sexual problems. Women also provided blood to establish CD4 cell count, serum total testosterone, and dehydroepiandrosterone sulfate (DHEAS) levels. RESULTS: Although overall levels of current Axis I diagnosis were low, Hypoactive Sexual Desire Disorder (HSDD) was diagnosed in 39% of the women. Forty-eight percent of the sample had deficient testosterone levels (below 20.0 ng/dl) and 27% had deficient DHEAS levels (below 35.0 microg/dl). We found no significant relationship between diminished sexual desire and deficient levels of testosterone, DHEAS, or mood disorder diagnoses. However, HSDD was significantly related to more depressive symptoms and lower life satisfaction. Women whose perceived risk factor for HIV infection included sexual contact were more than five times more likely to be diagnosed with a new onset HSDD than women who reported intravenous drug use (IVDU) as their only risk factor (47% vs. 9%, respectively). CONCLUSIONS: We observed what seems to be high rates of HSDD and endocrine abnormalities with very low rates of mood disorders. Interestingly, endocrine abnormalities were not associated with low sexual desire. Our findings suggest that there is a significant unmet need for treatment of Hypoactive Sexual Desire Disorder among urban HIV+ women.
机译：目的：这项探索性研究评估了情绪障碍，性障碍和内分泌异常的患病率，并探讨了HIV +妇女样本中这些参数之间的关系。方法：通过结构性临床访谈对DSM-III-R（SCID）评估了54名HIV +妇女，并评估了精神症状的严重程度，心理健康和性问题。妇女还提供血液以建立CD4细胞计数，血清总睾丸激素和硫酸脱氢表雄酮（DHEAS）水平。结果：尽管目前对I轴的诊断总体水平较低，但仍有39％的女性被诊断出性欲减退（HSDD）。 48％的样品睾丸激素水平不足（低于20.0 ng / dl），而27％的DHEAS水平不足（低于35.0 microg / dl）。我们发现性欲降低与睾丸激素，DHEAS或情绪障碍诊断水平不足之间没有显着关系。然而，HSDD与更多的抑郁症状和较低的生活满意度显着相关。与将静脉吸毒（IVDU）列为唯一危险因素的女性相比，其认为感染艾滋病毒的危险因素包括性接触的女性被诊断出新发HSDD的可能性高出五倍（分别为47％和9％） ）。结论：我们观察到HSDD和内分泌异常的发生率似乎很高，而情绪障碍的发生率却很低。有趣的是，内分泌异常与低性欲无关。我们的研究结果表明，城市HIV +妇女中对性欲减退的治疗存在大量未得到满足的需求。

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