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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Biopsychosocial Predictors of Health-Related Quality of Life in Patients With Chronic Hepatitis C.
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Biopsychosocial Predictors of Health-Related Quality of Life in Patients With Chronic Hepatitis C.

机译：慢性丙型肝炎患者健康相关生活质量的生物心理预测因子。

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OBJECTIVES: To assess biopsychosocial predictors of health-related quality of life (HRQOL) in patients with chronic hepatitis C. METHODS: In 94 consecutive patients with chronic hepatitis C attending a liver center, HRQOL was assessed by the Medical Outcome Study Short Form Health Survey 36 (SF-36) and by the German version of the Chronic Liver Disease Questionnaire. The predictive effect on HRQOL of disease-related worries measured by the worry subscale of the Chronic Liver Disease Questionnaire, psychiatric comorbidity (defined by at least one Hospital Anxiety and Depression Scale German Version Score >/=11), the Child-Pugh score in case of cirrhosis, interferon therapy, and active medical comorbidities was assessed by a multiple regression analysis. RESULTS: From 88 patients (age, 48.6 +/- 14.6 years; 50% female), 62 (70%) had no cirrhosis, 15 (17%) Child A, 5 (6%) Child B, and 6 patients (7%) Child C cirrhosis. The mental summary score of SF-36 was predicted by the amount of disease-related worries(corrected R(2) = 0.33; beta = 3.2; p < .001) and psychiatric comorbidity (corrected R(2) = 0.42; beta = -9.0; p < .001), by the physical summary score of SF-36 by the amount of disease related worries (corrected R(2) = 0.33; beta = 4.0; p < .001), and by the number of active medical comorbidities (corrected R(2) = 0.39; beta = -2.0; p = .006). CONCLUSIONS: The HRQOL in chronic hepatitis C is not determined by the severity of the liver disease but by psychiatric and medical comorbidities and disease-related worries.
机译：目的：为了评估慢性丙型肝炎患者健康相关生活质量（HRQOL）的生物心理社会预测因素。方法：在连续94名就诊于肝病中心的慢性丙型肝炎患者中，HRQOL由医学成果研究简式健康调查进行了评估36（SF-36）和德国版的《慢性肝病问卷》。通过慢性肝病问卷的忧虑量表，精神病合并症（至少由一项医院焦虑和抑郁量表，德语版评分> / = 11定义），Child-Pugh评分来衡量疾病相关忧虑对HRQOL的预测效果通过多元回归分析评估肝硬化，干扰素治疗和活动性合并症的病例。结果：在88例患者中（年龄为48.6 +/- 14.6岁;女性为50％），无肝硬化的有62例（70％），A子为15例（17％），B子为5例（6％），6例为患者（7 ％）儿童C肝硬化。 SF-36的心理简易评分由与疾病相关的担忧（校正后的R（2）= 0.33; beta = 3.2; p <.001）和精神病合并症（校正后的R（2）= 0.42; beta = -9.0; p <.001），通过SF-36的物理汇总评分，以及与疾病相关的忧虑量（校正后的R（2）= 0.33; beta = 4.0; p <.001），以及活动次数医疗合并症（校正后的R（2）= 0.39;β= -2.0; p = 0.006）。结论：慢性丙型肝炎的HRQOL不是由肝病的严重程度决定的，而是由精神病和医学合并症以及与疾病相关的忧虑决定的。

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