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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Sleep Deprivation Affects Thermal Pain Thresholds but Not Somatosensory Thresholds in Healthy Volunteers.
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Sleep Deprivation Affects Thermal Pain Thresholds but Not Somatosensory Thresholds in Healthy Volunteers.

机译：睡眠剥夺影响健康志愿者的热痛阈值，但不影响体感阈值。

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OBJECTIVE: Sleep disturbances have been thought to augment pain. Sleep deprivation has been proven to produce hyperalgesic effects. It is still unclear whether these changes are truly specific to pain and not related to general changes in somatosensory functions. The aim of the present study was to evaluate the effect of total sleep deprivation on thermal pain thresholds (heat, cold) and pain complaints. Thermal detection thresholds (warmth, cold) were included as covariates to determine the contribution of somatosensory functions to changes in pain processing. METHODS: Twenty healthy volunteers were randomly assigned either to two nights of total sleep deprivation or to two nights of undisturbed night sleep. Sleep deprivation nights were separated by two days with normal night sleep. Heat and cold pain thresholds as well as warmth and cold detection thresholds were measured by use of a peltier thermode in the evening before and the morning after each deprivation or control night. Pain complaints were examined by use of a questionnaire in parallel. RESULTS: During treatment nights, sleep deprivation produced a significant overnight decrease in heat pain thresholds. Cold pain thresholds tended to decrease also during sleep deprivation, whereas the warmth and cold detection thresholds remained unaffected. Accordingly, no substantial contributions of the changes in thermal detection thresholds to the changes in thermal pain thresholds were determined by regression analyses. Pain complaints were not induced by sleep deprivation. CONCLUSIONS: The present findings suggest that sleep deprivation produces hyperalgesic changes that cannot be explained by nonspecific alterations in somatosensory functions.
机译：目的：睡眠障碍被认为会加剧疼痛。睡眠不足被证明会产生痛觉过敏作用。尚不清楚这些改变是否真正针对疼痛而与体感功能的一般改变无关。本研究的目的是评估总睡眠不足对热痛阈值（热，冷）和疼痛症状的影响。将热检测阈值（温暖，寒冷）作为协变量包括在内，以确定体感功能对疼痛过程变化的贡献。方法：将二十名健康志愿者随机分配到两夜的总睡眠剥夺或两夜的无扰夜睡眠中。睡眠剥夺夜与正常的夜间睡眠间隔两天。在每个剥夺或控制夜之前和之后的晚上和晚上，使用珀尔帖热疗仪来测量热和冷的疼痛阈值以及温暖和冷的检测阈值。通过并行使用问卷调查疼痛投诉。结果：在治疗之夜，睡眠不足导致夜间热痛阈值明显降低。在睡眠剥夺期间，冷痛阈值也趋于降低，而温暖和寒冷的检测阈值仍然不受影响。因此，通过回归分析没有确定热检测阈值的改变对热痛阈值的改变的实质贡献。睡眠不足并不是诱发疼痛的抱怨。结论：目前的发现表明睡眠剥夺会产生痛觉过敏改变，这不能用体感功能的非特异性改变来解释。

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