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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Mothers with breast cancer and their adult daughters: the relationship between mothers' reaction to breast cancer and their daughters' emotional and neuroimmune status.
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Mothers with breast cancer and their adult daughters: the relationship between mothers' reaction to breast cancer and their daughters' emotional and neuroimmune status.

机译：患有乳腺癌的母亲及其成年女儿：母亲对乳腺癌的反应与女儿的情绪和神经免疫状况之间的关系。

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OBJECTIVES: The objectives of this study were to assess the associations between psychologic distress of patients with breast cancer and of their adult daughters; and to assess the associations between mothers' psychologic distress and daughters' psychologic distress, stress hormone levels, natural cytotoxic activity (NCA), and Th1 cytokine secretion. METHODS: Eighty mothers with breast cancer and 80 adult daughters participated in the study. They completed the Symptom Check List (SCL-90R) questionnaire. In addition, daughters completed a set of questions on their health status and habits and on the effects of their mothers' disease on their own lives. Thirty milliliters of heparinized venous blood and a first early-morning urine sample were collected from daughters between 8:00 and 9:00 am. Spontaneous and interleukin-2 (IL-2)-induced NCA, in vitro IL-2 and IL-12 secretion, and levels of plasma cortisol and urinary catecholamines were tested in daughters. Forty-seven healthy women, age- and education-matched to daughters, completed the psychologic, immunologic, and hormonal tests, and served as a control group. RESULTS: Psychologic distress of mothers and daughters was highly correlated. However, mothers experienced a higher level of distress than daughters. Mothers with advanced disease and their daughters were more distressed than mothers with primary disease and their daughters. Daughters' distress was also related to their subjective caregiving burden and the frequency of meetings with mothers. Higher distressed daughters had lower IL-2-induced NCA and decreased in vitro IL-2 and IL-12 secretion. Norepinephrine secretion level mediated the relationship between daughters' level of distress and their immune functions. Cortisol mediated only the relationship between daughters' distress and IL-2 secretion. CONCLUSIONS: This initial study shows that the psychologic distress of mothers with breast cancer and that of their adult daughters are similar. Stress hormone secretions and immune functions of daughters are related to both their own and their mothers' psychologic distress.
机译：目的：本研究的目的是评估乳腺癌患者及其成年女儿的心理困扰之间的联系。并评估母亲的心理困扰与女儿的心理困扰，应激激素水平，自然细胞毒性活性（NCA）和Th1细胞因子分泌之间的关系。方法：八十名患有乳腺癌的母亲和80名成年女儿参加了这项研究。他们完成了症状检查表（SCL-90R）问卷。此外，女儿们完成了一系列有关其健康状况和习惯以及母亲疾病对自己生活的影响的问题。在上午8:00至上午9:00之间从女儿那里收集了30毫升肝素化静脉血和第一批清晨尿液样本。在女儿中测试了自发和白介素2（IL-2）诱导的NCA，体外IL-2和IL-12分泌以及血浆皮质醇和尿儿茶酚胺的水平。 47名年龄和文化程度与女儿相匹配的健康女性，完成了心理，免疫和激素测试，并作为对照组。结果：母亲和女儿的心理困扰高度相关。但是，母亲比女儿经历的苦难程度更高。患有晚期疾病的母亲及其女儿比患有原发性疾病的母亲及其女儿更痛苦。女儿的苦恼还与她们的主观照料负担和与母亲会面的频率有关。受苦程度较高的女儿的IL-2诱导的NCA较低，体外IL-2和IL-12的分泌减少。去甲肾上腺素的分泌水平介导女儿的苦恼程度与其免疫功能之间的关系。皮质醇仅介导女儿的窘迫与IL-2分泌之间的关系。结论：这项初步研究表明，患有乳腺癌的母亲和成年女儿的心理困扰相似。女儿的应激激素分泌和免疫功能与他们自己和母亲的心理困扰有关。

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