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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Interleukin-6 covaries inversely with cognitive performance among middle-aged community volunteers.
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Interleukin-6 covaries inversely with cognitive performance among middle-aged community volunteers.

机译：白细胞介素6与中年社区志愿者的认知能力呈反相关。

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摘要

OBJECTIVE: Recent evidence suggests that higher peripheral levels of interleukin 6 (IL-6) are associated with poorer cognitive function and predict future cognitive decline among the elderly. The current investigation extends the study of relationships between plasma IL-6 and cognitive performance to healthy middle-aged adults and to an examination of more specific cognitive domains. METHODS: Five hundred relatively healthy community volunteers aged 30 to 54 had blood drawn for the determination of plasma IL-6 levels and completed a battery of neuropsychological tests evaluating memory and executive function. RESULTS: After controlling for age, gender, race, and education, hierarchical regression analyses revealed an inverse relationship between circulating levels of IL-6 and performance on clusters of tests assessing auditory recognition memory, attention/working memory, and executive function. In contrast, there was no association between IL-6 and performance on tests of general memory. Secondary analyses demonstrated that relationships between IL-6 and auditory recognition and working memory and executive function were independent of a number of health factors, including body mass index, smoking, and hypertension. CONCLUSIONS: These findings contribute to a growing body of evidence linking chronic inflammation to poorer cognitive functioning and extend these findings to a midlife community sample, raising the possibility that IL-6 may represent a biomarker for risk of future cognitive decline.
机译：目的：最新证据表明，外周血白介素6（IL-6）水平升高与较弱的认知功能有关，并预测老年人的未来认知能力下降。当前的研究将血浆IL-6与认知能力之间的关系的研究扩展到健康的中年成年人，并扩展到更具体的认知领域的检查。方法：从300名年龄在54至30岁之间的相对健康的社区志愿者抽取血液以测定血浆IL-6水平，并完成了一系列神经心理学测试，以评估记忆和执行功能。结果：在控制了年龄，性别，种族和受教育程度之后，层次回归分析显示IL-6的循环水平与评估听觉识别记忆，注意力/工作记忆和执行功能的一系列测试之间呈反比关系。相反，在一般记忆力测试中，IL-6与表现之间没有关联。次要分析表明，IL-6与听觉识别，工作记忆和执行功能之间的关系独立于许多健康因素，包括体重指数，吸烟和高血压。结论：这些发现促进了越来越多的证据将慢性炎症与较差的认知功能联系起来，并将这些发现扩展至中年社区样本，从而增加了IL-6可能代表未来认知能力下降风险的生物标志物的可能性。

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