• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Increased serum levels of 8-hydroxy-2'-deoxyguanosine in clinical depression.
【24h】

Increased serum levels of 8-hydroxy-2'-deoxyguanosine in clinical depression.

机译：临床抑郁症患者血清中的8-羟基-2'-脱氧鸟苷水平升高。

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: We sought to understand the pathophysiological effects of depression by examining group differences in serum levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), a biomarker of oxidative damage. METHODS: Our sample consisted of 169 participants. Eight-four of these participants met diagnostic criteria for clinical depression. The 85 participants in our comparison group were matched on age, gender, and ethnicity to the depressed group. 8-OHdG was measured by enzyme-linked immunosorbent assay. RESULTS: After adjusting for age, gender, race/ethnicity, years of education, daily smoking, average number of alcoholic drinks per week, average amount of physical activity per week, and body mass index, participants in the depressed group had significantly higher levels of oxidative DNA damage compared with participants in the control group. Pairwise comparisons showed that participants with major depression had significantly higher levels of 8-OHdG than control subjects and marginally higher levels of 8-OHdG compared with those with minor depression. Furthermore, participants with recurrent episodes of depression had more oxidative damage than participants with single episodes, who in turn had more damage than healthy control subjects. Finally, participants with recurrent episodes of major depression had more DNA damage than other depressed participants, who in turn had more damage than healthy control subjects. CONCLUSIONS: Our findings suggest that increased oxidative damage may represent a common pathophysiological mechanism, whereby depressed individuals become vulnerable to comorbid medical illness.
机译：目的：我们通过研究血清氧化损伤生物标志物8-羟基-2'-脱氧鸟苷（8-OHdG）的血清水平差异来了解抑郁症的病理生理作用。方法：我们的样本包括169名参与者。这些参与者中有八分之四符合临床抑郁症的诊断标准。比较组的85名参与者在年龄，性别和种族方面与抑郁组相当。通过酶联免疫吸附测定法测量8-OHdG。结果：在对年龄，性别，种族/民族，受教育年限，每日吸烟，每周平均酒精饮料数量，每周平均身体活动量以及体重指数进行调整之后，抑郁组的参与者的水平明显更高与对照组相比，氧化性DNA损伤的风险。配对比较显示，与轻度抑郁者相比，重度抑郁者的8-OHdG水平明显高于对照组，而8-OHdG的水平略高。此外，与单发发作相比，复发性抑郁发作的参与者氧化损伤更大，而单发发作的参与者比健康对照组的损伤更大。最后，复发性重度抑郁发作的参与者的DNA损伤比其他抑郁症的参与者要多，而其他抑郁症的参与者则比健康对照受试者的DNA损伤更大。结论：我们的研究结果表明，氧化损伤的增加可能代表了一种常见的病理生理机制，从而使抑郁的人易患合并症。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号