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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Reduction in allostatic load in older adults is associated with lower all-cause mortality risk: MacArthur studies of successful aging.
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Reduction in allostatic load in older adults is associated with lower all-cause mortality risk: MacArthur studies of successful aging.

机译：降低成年人的同素负荷与降低全因死亡率风险有关：麦克阿瑟成功衰老的研究。

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OBJECTIVES: To study the association between change in allostatic load (a risk score constructed from multiple biological markers) over a 2.5-year period and mortality in the following 4.5 years in older adults. METHODS: We measured 10 physiologic parameters at baseline (1988) in a cohort of 171 high-functioning, community-dwelling, 70- to 79-year-old adults. These measurements were repeated 2.5 years later, in 1991. Summary allostatic load scores for 1988 and 1991 were created as the weighted sum of the 10 biological markers and their second-order terms. Mortality status (alive or dead) for participants was determined 4.5 years later, in 1995. The association between change in allostatic load score (1988-1991) and subsequent mortality (1991-1995) was studied using logistic regression. RESULTS: Compared with participants whose allostatic load score decreased between 1988 and 1991, individuals whose allostatic load score increased had higher risk of all-cause mortality between 1991 and 1995 (15% versus 5%, p = .047). Adjusted for age and baseline allostatic load, each unit increment in the allostatic load change score was associated with mortality odds ratio of 3.3 (95% confidence interval, 1.1-9.8). CONCLUSION: Our results suggest that even in older ages, change in risk scores can be followed to improve assessment of mortality risk.
机译：目的：研究2。5年内的同种异体负荷（由多种生物学标志物构建的危险评分）的变化与以后4。5年内老年人的死亡率之间的关系。方法：我们在基线（1988年）的一组171位高功能，社区居住的70至79岁成年人中测量了10个生理参数。 2.5年后，即1991年，重复进行了这些测量。创建了1988年和1991年的总同素异能负荷评分，作为10个生物标志物及其二阶项的加权总和。在4.5年后的1995年确定了参与者的死亡率（存活或死亡）状态。使用logistic回归研究了恒重负荷评分变化（1988-1991）与随后的死亡率（1991-1995）之间的关系。结果：与1988年至1991年间同化负荷评分降低的参与者相比，其同化负荷评分升高的个体在1991年至1995年间具有更高的全因死亡率风险（15％比5％，p = .047）。调整了年龄和基线同情负荷后，同情负荷变化评分的每单位增量与死亡率的优势比为3.3（95％置信区间1.1-9.8）相关。结论：我们的结果表明，即使在老年人中，也可以遵循风险评分的变化来改善对死亡风险的评估。

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