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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >The association of social status and blood pressure with markers of vascular inflammation.
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The association of social status and blood pressure with markers of vascular inflammation.

机译：社会地位和血压与血管炎症标志物的关系。

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OBJECTIVE: Low socioeconomic status (SES) is associated with low-grade inflammation. Vascular inflammation often accompanies high blood pressure (BP) and has clinical implications for future vascular diseases, including atherosclerosis. Elevated plasma levels of soluble intercellular adhesion molecule-1 (sICAM-1) and endothelin-1 (ET-1) are reliable indicators of vascular inflammation. We examined the associations among BP, social status, and sICAM-1 and ET-1 levels in 121 European American and African American men and women. METHODS: Social status of the subjects was determined by using the Hollingshead Two Factor Index of Social Position scale, and plasma sICAM-1 and ET-1 levels were assessed using immunoassays. RESULTS: Correlation analyses revealed positive correlations among plasma sICAM-1 levels, BP, and social status. Levels of ET-1 were also significantly correlated with BP (p < .01) and social status (p < .001). When subjects were categorized into three social classes, sICAM-1 levels were significantly higher in the lowest social class as compared with the upper (p < .05) or middle (p < .01) class. The levels of ET-1 were higher in the low (p < .01) and middle (p < .05) social classes as compared with the upper class. Multiple hierarchic regression analyses revealed that even after controlling for demographic and health characteristics (gender, ethnicity, age, body mass index, and smoking) and systolic BP, social status accounted for additional variance of sICAM-1 or ET-1 levels. CONCLUSION: These results suggest that low-social-status individuals may incur risk for future vascular diseases through vascular inflammation.
机译：目的：低社会经济地位（SES）与轻度炎症相关。血管炎症通常伴随着高血压（BP），并且对未来的血管疾病（包括动脉粥样硬化）具有临床意义。血浆可溶性可溶性细胞间粘附分子1（sICAM-1）和内皮素1（ET-1）的水平升高是血管炎症的可靠指标。我们检查了121名欧美男性和女性的血压，社会地位以及sICAM-1和ET-1水平之间的关联。方法：使用Hollingshead社会地位两因素指数来确定受试者的社会地位，并使用免疫测定法评估血浆sICAM-1和ET-1水平。结果：相关分析显示血浆sICAM-1水平，血压和社会地位之间呈正相关。 ET-1水平也与BP（p <.01）和社会地位（p <.001）显着相关。将受试者分为三个社会阶层时，最低社会阶层的sICAM-1水平明显高于上层社会（p <.05）或中层社会（p <.01）。与上层社会相比，低层社会（p <.01）和中层社会（p <.05）的ET-1水平更高。多重层次回归分析显示，即使在控制了人口统计学和健康特征（性别，种族，年龄，体重指数和吸烟）和收缩压之后，社会地位还是sICAM-1或ET-1水平的额外差异。结论：这些结果表明，低社会地位的人可能通过血管发炎招致未来血管疾病的风险。

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