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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Comparison of generalized and localized hyperalgesia in patients with recurrent headache and fibromyalgia.
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Comparison of generalized and localized hyperalgesia in patients with recurrent headache and fibromyalgia.

机译：复发性头痛和纤维肌痛患者的全身性和局部性痛觉过敏的比较。

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OBJECTIVES: Research suggests that dysregulated pain modulation may play an important role in recurrent headaches and fibromyalgia syndrome (FMS). The primary objective of this study was to investigate algesic responses in localized cervical and pericranial regions (ie, headache-specific areas) and distal locations (ie, trochanter and gluteal) in patients with primary headaches (tension-type and migraine). The headache patients' algesic responses were compared with those of a sample of patients with musculoskeletal pain who report generalized hyperalgesia, or FMS. METHODS: Seventy patients with mixed headache diagnoses and 66 patients with FMS underwent a standardized examination of generalized hyperalgesia based on American College of Rheumatology criteria. RESULTS: Twenty-eight of the 70 headache patients reported the presence of widespread TP pain, suggesting generalized hyperalgesia. Headache diagnosis was unrelated to the presence or absence of generalized hyperalgesia. The subset of headache patients with generalized hyperalgesia did not differ from the FMS patients in pain sensitivity in the cervical and pericranial areas. Regression analyses revealed that pressure pain sensitivity was significantly related to self-reported pain only in the headache patients with generalized hyperalgesia. CONCLUSIONS: These results suggest that extensive dysregulation in pain modulation is important for a substantial minority of recurrent headache patients, who seem to be quite similar to FMS patients. Differential treatment planning targeting generalized hyperalgesia may be useful in treating headache patients exhibiting generalized hyperalgesia more effectively.
机译：目的：研究表明，疼痛调节失调可能在复发性头痛和纤维肌痛综合征（FMS）中起重要作用。这项研究的主要目的是研究原发性头痛（紧张型和偏头痛）患者在局部宫颈和颅骨区域（即头痛特定区域）和远端位置（即转子和臀肌）的止痛反应。将头痛患者的止痛反应与报告全身性痛觉过敏或FMS的肌肉骨骼疼痛患者的样本进行比较。方法：根据美国风湿病学会的标准，对70例混合头痛诊断患者和66例FMS患者进行了全身性痛觉过敏的标准化检查。结果：70例头痛患者中有28例报告存在广泛的TP疼痛，提示全身性痛觉过敏。头痛的诊断与是否存在全身性痛觉过敏无关。全身性痛觉过敏的头痛患者亚组与FMS患者在颈部和颅骨区域的疼痛敏感性无差异。回归分析显示，仅在全身性痛觉过敏的头痛患者中，压力疼痛敏感性与自我报告的疼痛显着相关。结论：这些结果表明，疼痛调节的广泛失调对于绝大部分复发性头痛患者很重要，这些患者似乎与FMS患者非常相似。针对全身性痛觉过敏的差异化治疗计划可能有助于更有效地治疗表现出全身性痛觉过敏的头痛患者。

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