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Depression and smoking in coronary heart disease.

机译:冠心病患者的抑郁和吸烟。

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摘要

OBJECTIVE: This review examines the relationship between depression and smoking in coronary heart disease (CHD). It summarizes relevant findings from general population and smoking cessation studies and discusses the few studies that have investigated whether smoking confounds, mediates, or moderates the effect of depression on cardiac morbidity and mortality. METHODS: Qualitative review of research literature. RESULTS: Although many studies of the prognostic importance of depression in CHD have adjusted for smoking, there is no convincing evidence that smoking actually confounds the relationship between depression and CHD. There is also no evidence that smoking moderates this relationship. There is, however, limited evidence that smoking may partially mediate the effect of depression on morbidity and mortality in CHD. CONCLUSION: We need more research on the relationship between depression and smoking in CHD to develop a more complete model of the mechanisms linking depression to cardiac morbidity and mortality.
机译:目的:本综述探讨了冠心病(CHD)中抑郁与吸烟之间的关系。它总结了来自一般人群和戒烟研究的相关发现,并讨论了一些调查吸烟是否混淆,介导或缓解了抑郁症对心脏发病率和死亡率的影响的研究。方法:对研究文献进行定性审查。结果:尽管许多关于冠心病抑郁的预后重要性的研究已经针对吸烟进行了调整,但没有令人信服的证据表明吸烟实际上混淆了抑郁与冠心病之间的关系。也没有证据表明吸烟可以缓解这种关系。但是,仅有有限的证据表明,吸烟可能部分介导抑郁对冠心病发病率和死亡率的影响。结论:我们需要对冠心病中抑郁与吸烟之间的关系进行更多研究,以建立更完整的抑郁症与心脏发病率和死亡率相关的机制模型。

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