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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Is there a functional neural correlate of individual differences in cardiovascular reactivity?
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Is there a functional neural correlate of individual differences in cardiovascular reactivity?

机译：心血管反应的个体差异是否存在功能性神经相关性？

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OBJECTIVE: The present study tested whether individuals who differ in the magnitude of their blood pressure reactions to a behavioral stressor also differ in their stressor-induced patterns of functional neural activation. METHODS: Sixteen participants (7 men, 9 women aged 47 to 72 years) were classified as high (n = 8) or low (n = 8) blood pressure reactors by the magnitude and temporal consistency of their systolic blood pressure (SBP) reaction to a Stroop color-word interference stressor. Both high and low SBP reactors completed this Stroop stressor while their task-related changes in blood pressure and functional neural activity were assessed in a blocked functional magnetic resonance imaging design. RESULTS: In both high and low SBP reactors, the Stroop-stressor engaged the anterior cingulate, orbitofrontal, insular, posterior parietal, and the dorsolateral prefrontal regions of the cortex, the thalamus, and the cerebellum. Compared with low reactors, however, high reactors not only showed a larger magnitude increase in SBP to the Stroop stressor, but also an increased activation of the posterior cingulate cortex. CONCLUSION: A behavioral stressor that is used widely in cardiovascular reactivity research, the Stroop stressor, engages brain systems that are thought to support both stressor processing and cardiovascular reactivity. Increased activation of the posterior cingulate, a brain region implicated in vigilance to the environment and evaluative emotional processes, may be a functional neural correlate of an individual's tendency to show large-magnitude (exaggerated) blood pressure reactions to behavioral stressors.
机译：目的：本研究测试了对行为应激源的血压反应幅度不同的个体在应激源诱导的功能性神经激活模式上是否也有所不同。方法：根据收缩压反应的幅度和时间一致性，将十六名参与者（7名男性，9名女性，年龄在47至72岁之间）分为高反应堆（n = 8）或低反应堆（n = 8）。 Stroop颜色词干扰应力源。高和低SBP反应堆都完成了Stroop应激源，同时在封闭的功能磁共振成像设计中评估了与任务相关的血压和功能神经活动变化。结果：在高和低SBP反应堆中，Stroop应激源均参与了前扣带，眶额，岛突，顶壁和皮质，丘脑和小脑的背外侧前额叶区域。然而，与低反应堆相比，高反应堆不仅显示出Stroop应激源的SBP幅度更大，而且后扣带回皮层的激活增加。结论：Stroop应激源是一种广泛用于心血管反应性研究的行为应激源，其参与的脑系统被认为既支持应激源的处理又支持心血管反应。后扣带回的增加的激活，这是一个警惕环境和评估情绪过程的大脑区域，可能与一个人对行为应激源表现出大幅度（夸大）的血压反应趋势的功能性神经相关。

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