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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Measuring health-related quality of life in patients with irritable bowel syndrome: can less be more?
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Measuring health-related quality of life in patients with irritable bowel syndrome: can less be more?

机译：测量肠易激综合症患者健康相关的生活质量：少可以多吗？

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OBJECTIVE: This study assessed the ability of a brief, well-validated generic health-related quality of life (HRQOL) measure to characterize the symptom burden of patients with irritable bowel syndrome (IBS) with reference to a large survey of U.S. community-living adults. METHODS: One hundred four Rome II diagnosed patients with IBS completed measures of pain, psychological dysfunction (neuroticism, somatization, distress, abuse), and HRQOL (SF-36, IBS-QOL, CDC HRQOL-4) during baseline assessment of a National Institutes of Health-funded clinical trial. The four-item CDC HRQOL-4 assesses global health and the number of days in the past 30 days resulting from poor physical health, poor mental health, and activity limitation. RESULTS: Patients with IBS averaged 15 of 30 days with poor physical or mental health. These average overall unhealthy days exceeded those of respondents with arthritis, diabetes, heart disease/stroke, cancer, and class III obesity (body mass index > or =40 kg/m2) from the U.S. survey. Fifteen percent of patients identified musculoskeletal disorders, not IBS symptoms, as the major cause of their activity limitation. Overall unhealthy days among patients with IBS varied directly with IBS symptom severity, abuse, pain, and psychological distress. Controlling for personality variables that influence perception and reporting HRQOL did not diminish the statistical significance of associations between the CDC HRQOL-4 and other study measures. CONCLUSIONS: The CDC HRQOL-4 is a psychometrically sound, rapid, and efficient instrument whose HRQOL profile reflects the symptom burden of moderate-to-severe IBS, is sensitive to treatment effects associated with cognitive behavior therapy, and is not a proxy for personality variables identified as potential confounders of HRQOL. HRQOL is related to but not redundant with psychological distress.
机译：目的：本研究参照美国社区生活的一项大规模调查，评估了一项简短且经过充分验证的通用健康相关生活质量（HRQOL）量度方法来表征肠易激综合征（IBS）患者的症状负担的能力大人。方法：在国家基线评估期间，一百四名经罗马二世诊断的IBS患者完成了疼痛，心理功能障碍（神经质，躯体化，困扰，虐待）和HRQOL（SF-36，IBS-QOL，CDC HRQOL-4）的测量卫生研究院资助的临床试验。 CDC HRQOL-4这四个项目评估了整体健康状况以及过去30天因身体状况不佳，心理健康状况不佳和活动受限而导致的天数。结果：IBS患者平均30天中有15天身体或精神健康较差。这些平均总体不健康天数超过了美国调查中患有关节炎，糖尿病，心脏病/中风，癌症和III级肥胖（体重指数≥40 kg / m2）的受访者。 15％的患者将肌肉骨骼疾病（而非IBS症状）确定为其活动受限的主要原因。 IBS患者的总体不健康天数直接随IBS症状严重程度，虐待，疼痛和心理困扰而变化。控制影响感知和报告HRQOL的人格变量并不能减少CDC HRQOL-4与其他研究指标之间关联的统计显着性。结论：CDC HRQOL-4是一种心理健康，快速且有效的仪器，其HRQOL概况反映了中度至重度IBS的症状负担，对与认知行为疗法相关的治疗效果敏感，而不是个性的代表确定为HRQOL潜在混杂因素的变量。 HRQOL与心理困扰有关但并非多余。

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