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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Autonomic and respiratory characteristics of posttraumatic stress disorder and panic disorder.
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Autonomic and respiratory characteristics of posttraumatic stress disorder and panic disorder.

机译：创伤后应激障碍和恐慌症的自主和呼吸特征。

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OBJECTIVE: Posttraumatic stress disorder (PTSD) and panic disorder (PD) are two anxiety disorders with prominent psychophysiological symptoms. The PTSD criterion of persistent hyperarousal suggests autonomic dysregulation, and the disorder has been associated with elevated heart rate. In contrast, PD has been associated with respiratory abnormalities such as low end-tidal Pco(2). An integrated analysis of automatic and respiratory function in a direct comparison of these anxiety disorders is currently lacking. METHODS: Electrodermal, cardiovascular, and respiratory psychophysiology was examined in 23 PTSD patients, 26 PD patients, and 32 healthy individuals at baseline and during threat of shock. RESULTS: At baseline, the PTSD patients, in contrast to the other two groups, were characterized by attenuated parasympathetic and elevated sympathetic control, as evidenced by low respiratory sinus arrhythmia (a measure of cardiac vagal control) and high electrodermal activity. They also displayed elevated heart rate and cardiovascular sympathetic activation in comparison with healthy controls. PD patients exhibited lower Pco(2) (hypocapnia) and higher cardiovascular sympathetic activation compared with healthy controls. PTSD patients, but not PD patients, sighed more frequently than controls. During the threat of shock phase, the PTSD group demonstrated blunted electrodermal responses. CONCLUSIONS: Persistent hyperarousal symptoms in PTSD seem to be due to high sympathetic activity coupled with low parasympathetic cardiac control. Respiratory abnormalities were also present in PTSD. Several psychophysiological measures exhibited group-comparison effect sizes in the order of 1.0, supporting their potential for enhancing differential diagnosis and possibly suggesting utility as endophenotypes in genetic studies of anxiety disorders.
机译：目的：创伤后应激障碍（PTSD）和恐慌症（PD）是两种具有明显的心理生理症状的焦虑症。持续性高听觉的PTSD标准提示自主神经功能失调，该疾病与心律加快有关。相反，PD已与呼吸系统异常相关，例如低潮气末Pco（2）。目前缺乏直接比较这些焦虑症的自动和呼吸功能综合分析。方法：在基线和休克威胁期间，对23例PTSD患者，26例PD患者和32例健康个体进行了皮肤，心血管和呼吸方面的心理生理检查。结果：在基线时，与其他两组相反，PTSD患者的特征是副交感神经减弱和交感神经控制升高，表现为低呼吸窦性心律不齐（一种测量心脏迷走神经的心律失常）和较高的皮肤电活动。与健康对照组相比，他们还表现出较高的心率和心血管交感神经激活。与健康对照组相比，PD患者表现出较低的Pco（2）（低碳酸血症）和较高的心血管交感神经激活。 PTSD患者而非对照组患者的叹气频率高于对照组。在休克威胁阶段，PTSD组表现出钝性的皮肤电反应。结论：PTSD持续性的高听觉症状似乎是由于高交感活动和低副交感心脏控制所致。 PTSD中也存在呼吸异常。几种心理生理指标显示出组比较效应的大小为1.0左右，这支持了它们增强鉴别诊断的潜力，并可能暗示了其在焦虑症基因研究中作为内表型的作用。

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