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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >P-wave dispersion in panic disorder.
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P-wave dispersion in panic disorder.

机译：恐慌症中的P波色散。

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BACKGROUND: P-wave dispersion (PWD) is defined as the difference between the maximum and the minimum P-wave (Pmax and Pmin, respectively) duration. Significant variation in cardiac atrial PWD has been correlated with changes in systemic autonomic tone such as during periods of anxiety. It is also known that the degree of PWD seen on 12-lead electrocardiogram (ECG) may be a predictor of susceptibility of the atrial myocardium to future atrial fibrillation (AF). Therefore, we firstly aimed to show an association between PWD and panic disorder, a state of high sympathetic tone. METHODS: PWD was measured in 40 outpatients with panic disorder and in 40 physically and mentally healthy age- and gender-matched controls. In addition, the Panic Agoraphobia Scale (PAS) and the Hamilton Depression Rating Scale (HDRS) were scored concomitantly. RESULTS: Both Pmax and Pmin were significantly higher than those of healthy controls. PWD was significantly greater in the panic disorder group than in the controls. As expected, the mean score on PAS was significantly higher for the panic disorder group than for the controls and correlated significantly with PWD. Heart rate (measured as RR intervals in milliseconds on electrocardiogram) did not differ significantly between the groups. CONCLUSIONS: The findings of the present study suggest that the disorder may be associated with an increase in PWD. This association may result from prolonged anxiety and increase in sympathetic modulation, which are main characteristics of panic disorder.
机译：背景技术：P波色散（PWD）定义为最大和最小P波持续时间（分别为Pmax和Pmin）之间的差。心脏心房PWD的显着变化已与全身性自主神经变化（如焦虑期）相关。还已知在12导联心电图（ECG）上看到的PWD程度可能是预测心房心肌对未来心房纤颤（AF）的敏感性。因此，我们首先旨在显示PWD与恐慌症（一种高交感状态）之间的关联。方法：对40名恐慌症患者以及40名年龄和性别相匹配的身心健康患者进行了PWD测量。此外，同时评估了恐慌性恐惧症量表（PAS）和汉密尔顿抑郁量表（HDRS）。结果：Pmax和Pmin均显着高于健康对照组。惊恐障碍组的PWD明显高于对照组。不出所料，恐慌症组的PAS平均得分显着高于对照组，并且与PWD显着相关。两组之间的心率（以心电图上以RR为间隔的毫秒数测量）无显着差异。结论：本研究发现提示该疾病可能与PWD升高有关。这种联系可能是由于焦虑症的持续时间延长和交感神经调节能力增强而引起的，这是恐慌症的主要特征。

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