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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Disturbed glucose disposal in patients with major depression; application of the glucose clamp technique.
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Disturbed glucose disposal in patients with major depression; application of the glucose clamp technique.

机译：重度抑郁症患者的葡萄糖处置不佳;葡萄糖钳技术的应用。

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OBJECTIVE: To assess the whole-body glucose disposal in patients with both typical and atypical depression and to characterize the neuroendocrine responses during a hyper-, eu-, hypoglycemic stepwise clamp experiment in patients with both subtypes of major depression. Depressive disorders and alterations in glucose metabolism are closely associated. The glucose clamp technique is considered to be the "gold standard" for the assessment of whole-body glucose disposal. METHODS: We studied 19 patients with typical major depressive disorder (MDD), 7 patients with atypical major depression, and 30 men and women of a healthy comparator group using a stepwise glucose clamp procedure. Glucose disposal rates were assessed and concentrations of hormones involved in glucose allocation were measured. RESULTS: Glucose disposal rates were lower by 19% in patients with typical MDD and 30% in patients with atypical MDD than in the group of healthy controls (3.2 +/- 0.8 and 2.8 +/- 0.7 versus 4.0 +/- 1.0 mmol h(-1) kg(-1)). C-peptide concentrations were 26% higher in patients with atypical MDD and similar in patients with typical MDD and healthy controls. Vascular endothelial growth factor concentrations were 30% higher in typical MDD and similar in atypical MDD and the control group. CONCLUSIONS: Whole-body glucose disposal is reduced in patients with typical and atypical depression. The observed neuroendocrine responses suggest a hyperactive allocation system in typical depression and a hypoactive allocation system in atypical depression.
机译：目的：评估伴有严重抑郁症两种亚型的高，正常，降血糖逐步钳夹实验中典型和非典型抑郁症患者的全身葡萄糖处置情况，并表征神经内分泌反应。抑郁症和葡萄糖代谢改变密切相关。葡萄糖钳夹技术被认为是评估全身葡萄糖处置的“金标准”。方法：我们采用逐步葡萄糖钳位法研究了19例典型的重度抑郁症（MDD），7例非典型性重度抑郁症患者和30名健康对照者。评估了葡萄糖的处置率，并测量了参与葡萄糖分配的激素浓度。结果：与正常对照组相比，典型MDD患者的葡萄糖处置率降低了19％，非典型MDD患者的葡萄糖处置率降低了（3.2 +/- 0.8和2.8 +/- 0.7与4.0 +/- 1.0 mmol·h （-1）公斤（-1））。非典型MDD患者的C肽浓度高26％，典型MDD患者和健康对照者的C肽浓度相似。在典型的MDD中，血管内皮生长因子浓度高出30％，在非典型MDD中与对照组相似。结论：典型和非典型抑郁症患者的全身葡萄糖处置减少。观察到的神经内分泌反应提示典型抑郁症患者的活动过度分配系统，非典型抑郁症患者的活动过度分配系统。

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