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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Perceived stress and psychological well-being are associated with antibody status after meningitis C conjugate vaccination.
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Perceived stress and psychological well-being are associated with antibody status after meningitis C conjugate vaccination.

机译：丙型脑膜炎共轭疫苗接种后，感知的压力和心理健康与抗体状态相关。

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摘要

OBJECTIVE: Psychological stress has been associated with reduced immune response to a variety of vaccinations. This study is the first to examine antibody status after vaccination with a conjugate vaccine, in which a polysaccharide antigen is conjugated to a protein to elicit a thymus-dependent antibody response. METHODS: Sixty undergraduate students, who had received the meningitis C conjugate vaccine before recruitment, attended a single testing session. They provided a blood sample and completed a battery of questionnaires, including the Life Events Scale for Students, Perceived Stress Scale, and General Health Questionnaire (GHQ-28). Both meningitis C-specific antibody titer and the serum bactericidal assay titer to whole meningitis C bacteria were assayed. RESULTS: High perceived stress, but not life events stress, was associated with low antibody titers. Poor antibody titers were also predicted by relatively low levels of psychological well-being as measured by the GHQ-28. Of the GHQ-28 subscales, anxiety/insomnia and social dysfunction were associated with antibody status. No psychological variables emerged from bivariate analyses as predictive of the adequacy of bactericidal titer. CONCLUSIONS: This study provides the first evidence that antibody status after a conjugate vaccination may be susceptible to psychological influences.
机译：目的：心理压力与对多种疫苗的免疫反应降低有关。这项研究是第一个在结合疫苗接种后检查抗体状态的研究，在结合疫苗中，多糖抗原与蛋白质结合以引发胸腺依赖性抗体应答。方法：60名在招募前接种过丙型脑膜炎疫苗的大学生参加了一次测试。他们提供了血液样本并完成了一系列问卷调查，包括针对学生的生活事件量表，感知压力量表和一般健康问卷（GHQ-28）。同时测定了C型脑膜炎特异性抗体滴度和全C型脑膜炎细菌的血清杀菌法滴度。结果：较高的感知压力而非生活事件压力与抗体效价低有关。 GHQ-28测得的心理健康水平相对较低，也可预测抗体效价低下。在GHQ-28分量表中，焦虑/失眠和社交功能障碍与抗体状态相关。双变量分析未显示任何心理变量可作为杀菌效价的预测指标。结论：这项研究提供了第一个证据，表明结合疫苗接种后的抗体状态可能易受心理影响。

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