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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Stressful life events precede exacerbations of multiple sclerosis.
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Stressful life events precede exacerbations of multiple sclerosis.

机译：应激性生活事件在多发性硬化症恶化之前发生。

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OBJECTIVE: We longitudinally monitored life events and health changes in patients with multiple sclerosis (MS) to determine whether stressful events may trigger exacerbation of MS. METHODS: Twenty-three women with MS were followed for 1 year. Each subject completed the Psychiatric Epidemiologic Research Interview on a weekly basis. Further information on potentially stressful events was acquired using the Life Events and Difficulties Schedule. Neurologic symptoms were also monitored on a weekly basis throughout the year. Potential MS exacerbations were confirmed by a neurologist who was blind to the presence and timing of stressors. RESULTS: Eighty-five percent of MS exacerbations were associated with stressful life events in the preceding 6 weeks. Stressful life events occurred an average of 14 days before MS exacerbations, compared with 33 days before a randomly selected control date (p <.0001). Survival analysis confirmed that an increase in frequency of life events was associated with greater likelihood of MS exacerbations (hazard ratio = 13.18, p <.05). CONCLUSIONS: These results are consistent with the hypothesis that stress is a potential trigger of disease activity in patients with relapsing-remitting MS.
机译：目的：我们纵向监测多发性硬化症（MS）患者的生活事件和健康变化，以确定压力事件是否可能引发MS恶化。方法：23例MS患者随访1年。每个受试者每周完成一次精神病流行病学研究访谈。使用“生活事件和困难时间表”获得了有关潜在压力事件的更多信息。全年也每周监测神经系统症状。一位可能对应激源的存在和时间视而不见的神经科医师证实了潜在的MS加重。结果：在前6周中，百分之八十五的MS加重与压力性生活事件相关。应激性生活事件平均在MS加重前14天发生，而随机选择的对照日期之前为33天（p <.0001）。生存分析证实，生活事件发生频率的增加与MS加重的可能性更大（危险比= 13.18，p <.05）。结论：这些结果与以下假设一致：应激是复发缓解型MS患者疾病活动的潜在触发因素。

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