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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Stress, coping, and hepatitis B antibody status.
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Stress, coping, and hepatitis B antibody status.

机译：压力，应对和乙型肝炎抗体状态。

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OBJECTIVE: The present study investigated the association between exposure to stressful life events, coping style, and antibody status after hepatitis B vaccination. METHODS: Two hundred sixty medical school undergraduates, who had received the three-dose hepatitis B vaccine before recruitment to this study, completed questionnaires measuring exposure to stressful life events during the past year, customary coping strategies, and health behaviors. Antibodies against hepatitis B surface antigen were determined; levels <100 mIU/ml were deemed inadequate. RESULTS: Two participant cohorts were identified: those vaccinated within the last year and those vaccinated earlier. In the early vaccination cohort, participants with greater-than-average stress exposures had a more than two-fold increased risk of having an inadequate antibody titer. Coping by accepting the reality of stressful situations proved protective, whereas coping by substance use increased the risk of having an inadequate antibody count in this cohort. These associations remained significant after adjustment for possible mediators. Furthermore, the effects of stress and coping were largely independent of one another. Neither stress nor coping was significantly associated with antibody status in the recently vaccinated cohort. CONCLUSIONS: The present study confirms that the immune system is sensitive to variations in psychological factors. Stressful life events and coping strategy seem to have a continuing impact on hepatitis B antibody status.
机译：目的：本研究调查了暴露于应激性生活事件，应对方式和乙肝疫苗接种后抗体状态之间的关系。方法：260名医学院本科生在参加该研究之前已接受了三剂乙型肝炎疫苗的接种，完成了调查表，以测量过去一年中生活在应激性生活中的暴露程度，习惯应对策略和健康行为。确定了针对乙肝表面抗原的抗体;水平<100 mIU / ml被认为是不足的。结果：确定了两个参与者队列：在去年内接种疫苗的人群和较早接种疫苗的人群。在早期疫苗接种队列中，暴露于高于平均水平的压力暴露的参与者抗体滴度不足的风险增加了两倍以上。接受紧张局势的现实应对证明是有保护作用的，而通过药物滥用应对可以增加该人群中抗体计数不足的风险。在对可能的调解人进行调整之后，这些关联仍然很重要。此外，压力和应对的效果在很大程度上彼此独立。在最近接种的人群中，压力和应对均与抗体状态无显着相关。结论：本研究证实免疫系统对心理因素的变化敏感。紧张的生活事件和应对策略似乎对乙型肝炎抗体状态具有持续的影响。

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