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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Covariation of psychosocial characteristics associated with cardiovascular disease: genetic and environmental influences.
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Covariation of psychosocial characteristics associated with cardiovascular disease: genetic and environmental influences.

机译：与心血管疾病相关的社会心理特征的协变：遗传和环境影响。

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OBJECTIVE: Three psychosocial characteristics associated with cardiovascular disease (CVD)-depression, hostility, and social support-tend to correlate with one another. However, the causes of each characteristic and why they tend to co-occur are not completely understood. Therefore, the current study used a twin design to examine the relative contributions of genetic and environmental influences to the variation and covariation of these three psychosocial characteristics. METHODS: The sources of variation and covariation among the Beck Depression Inventory, the Cook-Medley Hostility Scale, and the Interpersonal Support Evaluation List were examined in a young adult community sample of 157 monozygotic and 75 dizygotic twin pairs. RESULTS: Phenotypic confirmatory factor analysis indicated that a single latent factor could account for their moderate intercorrelations. Twin analyses indicated that the Beck Depression Inventory and Interpersonal Support Evaluation List were each influenced by genetic and nonshared environmental factors, whereas the Cook-Medley Hostility Scale was influenced by familial (genetic and/or shared environmental) and nonshared environmental factors. Bivariate associations between these scales were largely determined by common genetic effects and, to a lesser degree, common nonshared environmental effects. Covariation among the three scales could be explained by a single common genetic factor and a common nonshared environmental factor. Environmental factors shared within families did not contribute to covariation among the psychosocial characteristics. CONCLUSIONS: The results challenge the conventional approach of examining these psychosocial variables as independent risk factors for cardiovascular disease and argue for the importance of investigating specific causes for their covariation.
机译：目的：与心血管疾病（CVD）相关的三个社会心理特征-抑郁，敌意和社会支持倾向于相互关联。但是，每个特征的原因以及它们为什么同时出现的原因尚未完全了解。因此，当前的研究使用双胞胎设计来检验遗传和环境影响对这三种社会心理特征的变异和协变的相对贡献。方法：在一个年轻的成人社区样本中，对157个单卵双胞胎和75个双卵双胞胎对进行了调查，研究了贝克抑郁量表，库克-梅德利敌对量表和人际支持评估表之间的变异和协变量。结果：表型验证性因子分析表明，单个潜在因子可以解释它们的中等相互关系。双胞胎分析表明，贝克抑郁量表和人际支持评估表各受遗传和非共享环境因素的影响，而库克-梅德利敌对量表受家庭（遗传和/或共享环境）和非共享环境因素的影响。这些量表之间的双变量关联在很大程度上取决于常见的遗传效应，而在较小程度上取决于常见的非共有环境效应。这三个量表之间的协变可以用一个共同的遗传因素和一个共同的非共享环境因素来解释。家庭内部共享的环境因素并没有助长社会心理特征之间的协变。结论：结果挑战了将这些社会心理变量作为心血管疾病独立危险因素进行检查的常规方法，并提出了调查其协变具体原因的重要性。

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