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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Caffeine Affects Cardiovascular and Neuroendocrine Activation at Work and Home.
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Caffeine Affects Cardiovascular and Neuroendocrine Activation at Work and Home.

机译：咖啡因影响工作和家庭中的心血管和神经内分泌激活。

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OBJECTIVE: This study investigated the effects of moderate doses of caffeine on ambulatory blood pressure and heart rate, urinary excretion of epinephrine, norepinephrine, and cortisol, and subjective measures of stress during normal activities at work and at home in the evening. METHODS: Healthy, nonsmoking, habitual coffee drinkers (N = 47) participated in 3 days of ambulatory study. After a day of ad lib caffeine consumption, caffeine (500 mg) and placebo were administered double-blind in counter-balanced order on separate workdays. Ambulatory blood pressure and heart rate were monitored from the start of the workday until bedtime. Urinary excretion of catecholamines and cortisol was assessed during the workday and evening. RESULTS: Caffeine administration significantly raised average ambulatory blood pressure during the workday and evening by 4/3 mm Hg and reduced average heart rate by 2 bpm. Caffeine also increased by 32% the levels of free epinephrine excreted during the workday and the evening. In addition, caffeine amplified the increases in blood pressure and heart rate associated with higher levels of self-reported stress during the activities of the day. Effects were undiminished through the evening until bedtime. CONCLUSIONS: Caffeine has significant hemodynamic and humoral effects in habitual coffee drinkers that persist for many hours during the activities of everyday life. Furthermore, caffeine may exaggerate sympathetic adrenal-medullary responses to the stressful events of normal daily life. Repeated daily blood pressure elevations and increases in stress reactivity caused by caffeine consumption could contribute to an increased risk of coronary heart disease in the adult population.
机译：目的：本研究调查了适量咖啡因对动态血压和心率，肾上腺素，去甲肾上腺素和皮质醇的尿排泄以及在工作和晚上在家中正常活动期间主观压力的影响。方法：健康，无烟，习惯性饮咖啡者（N = 47）参加了为期3天的动态研究。每天随意摄入咖啡因后，在不同的工作日以平衡的方式对咖啡因（500毫克）和安慰剂进行双盲给药。从工作日开始到就寝前，都要监测动态血压和心率。在工作日和晚上评估儿茶酚胺和皮质醇的尿排泄量。结果：咖啡因的使用显着提高了工作日和晚上的平均门诊血压4/3 mm Hg，并使平均心率降低了2 bpm。咖啡因在工作日和傍晚排出的游离肾上腺素水平也增加了32％。此外，咖啡因在一天的活动中放大了血压和心率的升高，并伴随着较高水平的自我报告的压力。直到晚上睡觉前，效果一直没有减弱。结论：咖啡因在习惯的咖啡饮用者中具有显着的血液动力学和体液作用，这些饮用者在日常生活中持续多个小时。此外，咖啡因可能会加剧对正常日常生活压力事件的交感性肾上腺髓质反应。每天因咖啡因而引起的血压反复升高和应激反应性增加可能导致成年人口患冠心病的风险增加。

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