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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Change in forced expiratory volume in 1 second after sham bronchoconstrictor in suggestible but not suggestion-resistant asthmatic subjects: a pilot study.
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Change in forced expiratory volume in 1 second after sham bronchoconstrictor in suggestible but not suggestion-resistant asthmatic subjects: a pilot study.

机译：提示性但非提示抗性的哮喘受试者在深支气管狭窄术后1秒内强迫呼气量的变化：一项初步研究。

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OBJECTIVE: Randomized controlled trials in asthma often demonstrate a benefit from placebo interventions, although no study has yet characterized this group of placebo responders. Literature points to the importance of suggestion in asthma, and we reasoned that patients' level of suggestibility might influence their likelihood of responding to placebo-like suggestion. METHODS: To determine whether suggestion differentially influenced airway tone in preselected suggestible compared with suggestion-resistant asthmatics, we performed a prospective, double-blind, crossover pilot study in which subjects were identified as being suggestible or suggestion-resistant using the Creative Imagination Scale. Responses to inhaled saline were assessed using FEV1 and a modified Borg scale after the suggestion that the saline was a bronchoconstrictor and subsequently a bronchodilator. RESULTS: Five of eight suggestible subjects compared with one of nine suggestion-resistant subjects demonstrated a fall in FEV1 greater than 150 ml in response to inhaled saline and suggestion of bronchoconstriction (p =.027). Fourteen subjects experienced dyspnea in response to sham bronchoconstrictor, but none reported increased dyspnea after sham bronchodilator. CONCLUSIONS: This is the first time that subjects with asthma have been categorized as suggestible or nonsuggestible with this distinction then used to predict response to an intervention. The results of this pilot study suggest that a subgroup of suggestible asthmatic patients is more likely to respond to a placebo-like sham bronchoconstriction challenge. The data support earlier observations that psychological factors may influence asthma, and provide insights into the placebo response.
机译：目的：尽管尚无针对这一组安慰剂反应者的研究，但哮喘随机对照试验通常证明可从安慰剂干预中获益。文献指出在哮喘中建议的重要性，我们认为患者的建议水平可能会影响他们对安慰剂样建议作出反应的可能性。方法：为了确定建议是否与建议抗药性哮喘患者相比，预选建议药对气道音调有不同的影响，我们进行了一项前瞻性，双盲，交叉的前瞻性研究，其中使用创意想象量表将受试者鉴定为建议药或建议药。在暗示盐水为支气管收缩剂并随后为支气管扩张剂后，使用FEV1和改良的Borg量表评估了对吸入盐水的反应。结果：八名可疑受试者中的五名与九名耐暗示性受试者中的一名相比，表现出FEV1的下降大于150毫升，这是由于吸入盐水和支气管收缩所致（p = .027）。十四名受试者对假支气管收缩剂有呼吸困难，但没有人报告假性支气管扩张剂后呼吸困难增加。结论：这是首次将哮喘患者分类为可提示性或不可提示性，然后用这种区别来预测对干预的反应。这项前瞻性研究的结果表明，一组可疑的哮喘患者更可能对安慰剂样的假支气管收缩挑战作出反应。数据支持较早的观察，即心理因素可能影响哮喘，并提供对安慰剂反应的见解。

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