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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Depressive symptoms moderate the influence of hostility on serum interleukin-6 and C-reactive protein.
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Depressive symptoms moderate the influence of hostility on serum interleukin-6 and C-reactive protein.

机译：抑郁症状减轻了敌对性对血清白介素6和C反应蛋白的影响。

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OBJECTIVE: Recent evidence suggests that depressive symptoms and hostility may act together, as interacting factors, to have an effect on the circulating levels of inflammatory markers relevant to coronary artery disease. Further research, however, is needed to clarify the nature of this interaction and to determine whether previous findings extend to older adults. In this report we examined the cross-sectional associations of depressive symptoms, hostility, and their interaction with circulating levels of two such inflammatory markers-interleukin-6 (IL-6) and C-reactive protein (CRP). METHODS: A total of 316 healthy, older adults underwent a blood draw for the assessment of serum IL-6 and CRP and completed the Beck Depression Inventory-II and the Cook-Medley Hostility Scale. Regression analyses were performed to examine depressive symptoms, hostility, and their interaction as predictors of serum IL-6 and CRP. RESULTS: After adjustment for demographic factors, cardiovascular risk factors, and health behaviors, we detected depressive symptoms x hostility interactions for serum IL-6 (DeltaR(2) = .027, p < .01) and CRP (DeltaR(2) = .015, p < .05). Simple slope analyses revealed that hostility was positively related to serum IL-6 only among individuals with higher depressive symptoms. The pattern of results was similar for serum CRP, although none of the simple slopes was significant. CONCLUSIONS: Our findings suggest that depressive symptoms may moderate the hostility-inflammation relationship such that hostility may augment inflammatory processes relevant to coronary artery disease only in the presence of depressive symptoms. Our results also extend previous findings from younger adults to older adults from the general community.
机译：目的：最近的证据表明，抑郁症状和敌意可能作为相互作用因素共同作用，对与冠心病相关的炎症标志物的循环水平产生影响。但是，需要进一步的研究来阐明这种相互作用的性质，并确定以前的发现是否适用于老年人。在本报告中，我们检查了抑郁症状，敌意及其与两种炎症标记物白细胞介素6（IL-6）和C反应蛋白（CRP）的循环水平之间的相互作用的横断面关联。方法：共有316名健康的老年人接受了抽血以评估血清IL-6和CRP，并完成了贝克抑郁量表II和库克-梅德利敌对量表。进行回归分析以检查抑郁症状，敌意及其相互作用，作为血清IL-6和CRP的预测因子。结果：在调整了人口统计学因素，心血管危险因素和健康行为之后，我们检测到抑郁症状x血清IL-6（DeltaR（2）= .027，p <.01）和CRP（DeltaR（2）= .015，p <.05）。简单的斜率分析显示，只有在抑郁症状较高的人群中，敌对性才与血清IL-6呈正相关。尽管简单的斜率均不显着，但血清CRP的结果模式相似。结论：我们的研究结果表明，抑郁症状可以缓解敌对与炎症的关系，因此，只有在存在抑郁症状的情况下，敌对可能会加剧与冠心病相关的炎症过程。我们的研究结果还将以前的发现从年轻的成年人扩展到了整个社区的老年人。

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