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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Preadolescents' somatic and cognitive-affective depressive symptoms are differentially related to cardiac autonomic function and cortisol: the TRAILS study.
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Preadolescents' somatic and cognitive-affective depressive symptoms are differentially related to cardiac autonomic function and cortisol: the TRAILS study.

机译：TRAILS研究显示，前身者的躯体和认知情感抑郁症状与心脏自主神经功能和皮质醇有不同的相关性。

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OBJECTIVE: To examine in a nonclinical sample of preadolescents the possibility that somatic and cognitive-affective depressive symptoms are differentially related with the autonomic nervous system (ANS) and the hypothalamic-pituitary-adrenal (HPA) axis. Depression is a well-known risk factor for cardiovascular disease and mortality. Dysregulation of the ANS and the HPA axis have been proposed as underlying mechanisms. Several studies suggest that only a subset of the depression symptoms account for associations with cardiovascular prognosis. METHODS: Self-reported somatic and cognitive-affective depressive symptoms were examined in relationship to heart rate variability (HRV), spontaneous baroreflex sensitivity (BRS), and the cortisol awakening response (CAR) in 2049 preadolescents (mean age = 11.1 years; 50.7% = girls) from the Tracking Adolescents' Individual Lives Survey (TRAILS). RESULTS: Physiological measurements were not associated with the overall measure of depressive symptoms. Somatic depressive symptoms were negatively related to HRV and BRS, and positively to the CAR; cognitive-affective depressive symptoms were positively related to HRV and BRS, and negatively to the CAR. Associations with the CAR pertained to boys only. CONCLUSIONS: Somatic and cognitive-affective depressive symptoms differ in their association with both cardiac autonomic and HPA axis function in preadolescents. Particularly, somatic depression symptoms may mark cardiac risk.
机译：目的：在非临床前青少年样本中检查躯体和认知影响的抑郁症状与自主神经系统（ANS）和下丘脑-垂体-肾上腺（HPA）轴差异相关的可能性。抑郁是心血管疾病和死亡率的众所周知的危险因素。已经提出ANS和HPA轴的失调是潜在的机制。多项研究表明，抑郁症状的一部分仅与心血管预后相关。方法：对2049名青少年（平均年龄= 11.1岁; 50.7岁）的自我报告的躯体和认知情感抑郁症状与心率变异性（HRV），自发压力反射敏感性（BRS）和皮质醇觉醒反应（CAR）的关系进行了研究。 ％=女孩），来自追踪青少年的个人生活调查（TRAILS）。结果：生理指标与抑郁症状的总体指标无关。躯体抑郁症状与HRV和BRS呈负相关，与CAR呈正相关。认知情感抑郁症状与HRV和BRS呈正相关，与CAR呈负相关。与CAR的关联仅与男孩有关。结论：青春期前的躯体和认知情感性抑郁症状与心脏自主神经和HPA轴功能的相关性不同。特别是，躯体抑郁症状可能标志着心脏风险。

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