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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Association of optimism and pessimism with inflammation and hemostasis in the Multi-Ethnic Study of Atherosclerosis (MESA).
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Association of optimism and pessimism with inflammation and hemostasis in the Multi-Ethnic Study of Atherosclerosis (MESA).

机译：在多族裔动脉粥样硬化研究（MESA）中，乐观和悲观与炎症和止血相关。

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OBJECTIVE: To investigate the association between optimism/pessimism and concentrations of seven inflammation and hemostasis markers. Optimism and pessimism are associated with cardiovascular disease mortality and progression; however, the biological mechanism remains unclear. METHODS: This cross-sectional study used data from the Multi-Ethnic Study of Atherosclerosis (MESA), a study of 6814 persons aged 45 to 84 years with no history of clinical cardiovascular disease. The Life-Orientation Test-Revised (LOT-R) was used to measure dispositional optimism and pessimism. Regression analyses were used to estimate associations of optimism and pessimism with interleukin (IL)-6, C-reactive protein (CRP), fibrinogen, homocysteine, Factor VIII, D-dimer, and plasmin-antiplasmin, before and after adjustment for sociodemographics, depression, cynicism, health behaviors, body mass index (BMI), hypertension, and diabetes. RESULTS: Higher scores on the LOT-R (positive disposition) were related to lower concentrations of IL-6 (p = .001), fibrinogen (p < .001), and homocysteine (p = .031). Associations were stronger for the pessimism subscale. After adjustment for demographics, the percentage differences in inflammatory markers corresponding to a 2-standard deviation increase in pessimism were 6.01% (p = .001) for IL-6, 10.31% (p = .001) for CRP, 2.47% (p < .0001) for fibrinogen, and 1.36% (p = .07) for homocysteine. Associations were attenuated but significant after adjustment for sociodemographics, depression, cynical distrust, and behaviors. Further adjustment for hypertension, BMI, and diabetes reduced associations for CRP and IL-6. Pessimism remained associated with a 1.36% (p = .02) increase in fibrinogen in the fully adjusted model. Factor VIII, D-dimer, and plasmin-antiplasmin were not associated with the LOT-R or subscales. CONCLUSIONS: Pessimism is related to higher levels of inflammation. Health behaviors, BMI, hypertension, and diabetes seem to play a mediating role.
机译：目的：探讨乐观/悲观情绪与7种炎症和止血指标浓度之间的关系。乐观和悲观与心血管疾病的死亡率和进展有关。然而，生物学机制仍不清楚。方法：这项横断面研究使用了来自多民族动脉粥样硬化研究（MESA）的数据，该研究对6814位年龄在45至84岁之间，无临床心血管疾病史的人进行了研究。经修订的生活取向测试（LOT-R）用于测量性格乐观和悲观情绪。在进行社会人口统计学调整之前和之后，使用回归分析来估计乐观和悲观与白介素（IL）-6，C反应蛋白（CRP），纤维蛋白原，高半胱氨酸，凝血因子VIII，D-二聚体和纤溶酶-抗纤溶酶的相关性，抑郁症，犬儒主义，健康行为，体重指数（BMI），高血压和糖尿病。结果：LOT-R（阳性倾向）得分较高与IL-6（p = .001），纤维蛋白原（p <.001）和同型半胱氨酸（p = .031）的较低浓度有关。悲观主义量表的关联性较强。经过人口统计学调整后，与悲观情绪的2个标准差增加相对应的炎性标志物百分比差异对于IL-6为6.01％（p = .001），对于CRP为10.31％（p = .001），为2.47％（p对于纤维蛋白原，<.0001），对于同型半胱氨酸，<1.30001（p = .07）。在对社会人口统计学，抑郁症，愤世嫉俗的不信任和行为进行调整之后，联想减弱，但意义显着。进一步调整高血压，BMI和糖尿病可降低CRP和IL-6的相关性。在完全调整的模型中，悲观情绪仍然与纤维蛋白原增加1.36％（p = .02）有关。 VIII因子，D-二聚体和纤溶酶-抗纤溶酶与LOT-R或分量表无关。结论：悲观情绪与较高的炎症水平有关。健康行为，BMI，高血压和糖尿病似乎起着中介作用。

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