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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Central nervous system serotonin and clustering of hostility, psychosocial, metabolic, and cardiovascular endophenotypes in men.
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Central nervous system serotonin and clustering of hostility, psychosocial, metabolic, and cardiovascular endophenotypes in men.

机译：中枢神经系统5-羟色胺和男性的敌意，心理，代谢和心血管内表型聚类。

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OBJECTIVE: To use measures of cerebrospinal fluid (CSF) 5-hydroxyindoleacetic acid (5HIAA) and genotype of a functional polymorphism of the monoamine oxidase A gene promoter (MAOA-uVNTR) to study the role of central nervous system (CNS) serotonin in clustering of hostility, other psychosocial, metabolic and cardiovascular endophenotypes. METHODS: In 86 healthy male volunteers, we evaluated CSF levels of the primary serotonin metabolite 5HIAA and MAOA-uVNTR genotype for association with a panel of 29 variables assessing hostility, other psychosocial, metabolic, and cardiovascular endophenotypes. RESULTS: The correlations of 5HIAA with these endophenotypes in men with more active MAOA-uVNTR alleles were significantly different from those of men with less active alleles for 15 of the 29 endophenotypes. MAOA-uVNTR genotype and CSF 5HIAA interacted to explain 20% and 22% of the variance, respectively, in scores on one factor wherein high scores reflected a less healthy psychosocial profile and a second factor wherein high score reflected increased insulin resistance, body mass index, blood pressure and hostility. In men with less active alleles, higher 5HIAA was associated with more favorable profiles of hostility, other psychosocial, metabolic and cardiovascular endophenotypes; in men with more active alleles, higher 5HIAA was associated with less favorable profiles. CONCLUSIONS: These findings indicate that, in men, indices of CNS serotonin function influence the expression and clustering of hostility, other psychosocial, metabolic and cardiovascular endophenotypes that have been shown to increase risk of developing cardiovascular disease. The findings are consistent with the hypothesis that increased CNS serotonin is associated with a more favorable psychosocial/metabolic/cardiovascular profile, whereas decreased CNS serotonin function is associated with a less favorable profile.
机译：目的：采用脑脊液（CSF）5-羟基吲哚乙酸（5HIAA）的检测方法和单胺氧化酶A基因启动子（MAOA-uVNTR）功能多态性的基因型，研究中枢神经系统（CNS）血清素在聚类中的作用敌对性，其他社会心理，代谢和心血管内表型。方法：在86名健康的男性志愿者中，我们评估了血清素主要代谢物5HIAA和MAOA-uVNTR基因型的脑脊液水平，与一组评估敌对性，其他社会心理，代谢和心血管内表型的29个变量相关联。结果：在29种内表型中，有15种MAOA-uVNTR等位基因活跃的男性中5HIAA与这些内表型的相关性与那些等位基因较少活性的男性中的5HIAA的显着不同。 MAOA-uVNTR基因型和CSF 5HIAA的相互作用分别解释了一个因素的得分的20％和22％，其中一个因素得分较高，其反映出较不健康的社会心理状况，而第二个因素得分较高，其反映出其胰岛素抵抗，体重指数增加，血压和敌意。在等位基因活性较低的男性中，较高的5HIAA与较有利的敌意，其他社会心理，代谢和心血管内表型有关;在等位基因活跃的男性中，较高的5HIAA与较差的特征有关。结论：这些发现表明，在男性中，中枢神经系统5-羟色胺功能指数影响敌对性，其他心理社会，代谢和心血管内表型的表达和聚集，这些表型已被证明会增加患心血管疾病的风险。该发现与假说CNS5-羟色胺增加与更有利的社会心理/代谢/心血管状况有关，而CNS 5-羟色胺功能下降与较不利的形象有关。

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