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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Autonomic and adrenocortical reactivity and buccal cell telomere length in kindergarten children.
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Autonomic and adrenocortical reactivity and buccal cell telomere length in kindergarten children.

机译：幼儿园儿童的自主神经和肾上腺皮质反应性以及颊细胞端粒长度。

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OBJECTIVE: To examine associations between autonomic nervous system and adrenocortical reactivity to laboratory stressors and buccal cell telomere length (BTL) in children. METHODS: The study sample comprised 78 children, aged 5 to 6 years, from a longitudinal cohort study of kindergarten social hierarchies, biologic responses to adversity, and child health. Buccal cell samples and reactivity measures were collected in the spring of the kindergarten year. BTL was measured by real-time polymerase chain reaction, as the telomere-to-single-copy gene ratio. Parents provided demographic information; parents and teachers reported children's internalizing and externalizing behavior problems. Components of children's autonomic (heart rate, respiratory sinus arrhythmia [RSA], and preejection period [PEP]) and adrenocortical (salivary cortisol) responses were monitored during standardized laboratory challenges. We examined relationships between reactivity, internalizing and externalizing behaviors, and BTL, adjusted for age, race, and sex. RESULTS: Heart rate and cortisol reactivity were inversely related to BTL, PEP was positively related to BTL, and RSA was unrelated to BTL. Internalizing behaviors were also inversely related to BTL (standardized beta = -0.33, p = .004). Split at the median of reactivity parameters, children with high sympathetic activation (decreasing PEP), and parasympathetic withdrawal (decreasing RSA) did not differ with regard to BTL. However, children with both this profile and high cortisol reactivity (n = 12) had significantly shorter BTL (0.80 versus 1.00; chi(2) = 7.6, p = .006), compared with other children. CONCLUSIONS: The combination of autonomic and adrenocortical reactivity was associated with shorter BTL in children. These data suggest that psychophysiological processes may influence, and that BTL may be a useful marker of, early biologic aging.
机译：目的：探讨自主神经系统与对实验室应激源的肾上腺皮质反应性和儿童颊颊细胞端粒长度（BTL）之间的关系。方法：该研究样本包括来自幼儿园社会阶层，对逆境的生物反应和儿童健康的纵向队列研究的78名5至6岁的儿童。在幼儿园的春季收集了颊细胞样品和反应性措施。 BTL通过实时聚合酶链反应测量，以端粒与单拷贝基因之比表示。父母提供了人口统计信息;父母和老师报告了孩子的内在和外在行为问题。在标准化实验室检查期间，监测了儿童自主神经（心率，呼吸窦性心律不齐[RSA]和射血前期[PEP]）和肾上腺皮质（唾液皮质醇）反应的组成。我们检查了反应性，内在和外在行为与BTL之间的关系，并根据年龄，种族和性别进行了调整。结果：心率和皮质醇反应性与BTL呈负相关，PEP与BTL呈正相关，而RSA与BTL无关。内部化行为也与BTL呈负相关（标准化的beta = -0.33，p = .004）。按反应性参数的中位数划分，具有高交感性激活（降低PEP）和副交感神经退缩（降低RSA）的儿童在BTL方面无差异。但是，与其他儿童相比，具有这种特征和高皮质醇反应性的儿童（n = 12）的BTL明显短（0.80对1.00; chi（2）= 7.6，p = .006）。结论：自主性和肾上腺皮质反应性的结合与儿童BTL缩短有关。这些数据表明，心理生理过程可能会影响早期生物衰老，并且BTL可能是早期生物学衰老的有用标志。

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