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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Mood patterns based on momentary assessment of positive and negative moods over a day and coronary artery calcification in the CARDIA study
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Mood patterns based on momentary assessment of positive and negative moods over a day and coronary artery calcification in the CARDIA study

机译：在CARDIA研究中，基于一天中对正面和负面情绪的瞬时评估以及冠状动脉钙化的情绪模式

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Objective: Retrospective assessments of negative mood have predicted coronary artery disease development and progression. Using momentary assessment, we evaluated associations between average positive and negative mood states and diurnal mood patterns, with prevalent and incident coronary artery calcification (CAC), a measure of calcified atherosclerosis. Methods: In a prospective cohort study of 669 white and African American men and women, aged 33 to 45 years, from the Coronary Artery Risk Development in Young Adults Study, mood was assessed at Year 15 examination, six times over a weekday. Prevalent, progressive, and 5-year incident CAC (any detectable CAC [score >0]) and substantial CAC (CAC score ≥ 20) were assessed at examinations at Years 15 and 20 by electron-beam tomographic scans. We employed a modified Poisson regression approach for binary data with robust error estimation to quantify relative risk. Results: In multivariate-adjusted analyses, those with high-average positive mood that improved over a day had a lower risk of prevalent CAC higher than 0 (relative risk [RR] = 0.17 [95% confidence interval {CI} = 0.04-0.67]) and substantial CAC (RR = 0.25 [95% CI = 0.06-0.95]). In contrast, those with high-average, increasingly negative mood over a day had a higher risk of prevalent CAC (RR = 1.85 [95% CI = 0.86-3.99]) and substantial CAC (RR = 3.11 [95% CI = 1.29-7.49]). Findings were similar for progressive CAC at Year 20. This pattern of high/worsening negative mood (not positive mood) during the day was also predictive of 5-year incident CAC (RR = 2.99 [95% CI = 1.00-8.93]). Conclusions: Diurnal mood patterns were associated with the progression of calcified atherosclerosis, with negative mood predicting greater progression and positive mood predicting lower progression. Abbreviations: CAC = coronary artery calcificationCARDIA = Coronary Artery Risk Development in Young AdultsCES-D = Center for Epidemiological Studies Depression ScaleCHD = coronary heart diseaseEBT = electron-beam tomographyHDL = high-density lipoproteinLDL = low-density lipoproteinRR = relative riskSBP = systolic blood pressure
机译：目的：回顾性评估负面情绪可以预测冠状动脉疾病的发生和发展。使用瞬时评估，我们评估了平均积极情绪状态和消极情绪状态与昼夜情绪模式之间的关联，以及普遍和入射的冠状动脉钙化（CAC）（一种衡量钙化动脉粥样硬化的指标）。方法：在一项针对前瞻性队列研究的669名年龄在33至45岁之间的白人和非洲裔美国人中，来自年轻人的冠状动脉风险发展研究中，在15年级考试中评估了情绪，一周中进行了六次。通过电子束断层扫描在15年和20年的检查中评估了普遍的，进行性的和5年事件的CAC（任何可检测到的CAC [得分> 0]）和基本CAC（CAC分数≥20）。我们对二进制数据采用了经过改进的Poisson回归方法，并通过鲁棒的误差估计来量化相对风险。结果：在多变量调整分析中，一天中情绪高涨且平均水平较高的患者，其普遍CAC风险低于0的风险较低（相对风险[RR] = 0.17 [95％置信区间{CI} = 0.04-0.67 ]）和基本的CAC（RR = 0.25 [95％CI = 0.06-0.95]）。相比之下，一天中平均情绪越来越高，越来越消极的人发生CAC的风险较高（RR = 1.85 [95％CI = 0.86-3.99]）和大量CAC（RR = 3.11 [95％CI = 1.29- 7.49]）。在20年级时，进行性CAC的发现相似。白天这种高/令人担忧的负面情绪（不是积极情绪）的模式也可预测5年事件的CAC（RR = 2.99 [95％CI = 1.00-8.93]）。结论：昼夜情绪模式与钙化动脉粥样硬化的进展有关，负情绪预示着更大的进展，正情绪预示着更低的进展。缩写：CAC =冠状动脉钙化CARDIA =青年人的冠状动脉风险发展CES-D =流行病学研究中心抑郁量表CHD =冠心病EBT =电子束断层扫描HDL =高密度脂蛋白LDL =低密度脂蛋白RR =相对风险SBP =收缩压

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