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Expanding options for developing outcome measures from momentary assessment data

机译：从瞬时评估数据中开发结局指标的扩展选择

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Objective: We propose several different patient-reported outcomes (PROs) from momentary, real-time collection of symptom data. In addition to the mean of momentary reports of symptoms, other types of summaries can reflect different aspects of the symptom experience. Methods: With secondary analyses of two studies of patients with chronic pain assessed with real-time methods, we demonstrate principles for developing outcomes that summarize symptom experience during a 1-week period. These studies focused on pain intensity, which is used to demonstrate methods for creating summary momentary measures. Results: Analyses from the first study (Pain 2008;139:146-57) yielded outcome measures based on the mean, median, 90th percentile, maximum, standard deviation, proportion of reports with no pain, proportion of reports with pain more than 50 (on a 0- to 100-point scale), and time-contingent measures. The second study examined the performance of these measures (and the mean) in a longitudinal study, in which some patients changed treatment (n = 78), making pain reduction likely, whereas others had no treatment change (n = 27). The measure that best discriminated the groups was the proportion of momentary reports without pain (effect size = 0.50), closely followed by the mean of all reports (effect size = 0.45). Most measures also correlated with patients' global impression of their change (between 0.39 and 0.55, except for standard deviation [0.13]). Conclusions: These analyses suggest that momentary symptom data can be useful for developing new PROs that reflect symptom experience other than the mean. They highlight knowledge gleaned from real-time studies, which deepens our understanding of symptoms by demonstrating which changes in symptoms are associated with overall perceived change.
机译：目的：我们从症状数据的瞬时，实时收集中提出几种不同的患者报告结局（PRO）。除了症状的瞬时报告的平均值以外，其他类型的摘要也可以反映症状体验的不同方面。方法：通过对两项采用实时方法评估的慢性疼痛患者的研究进行的二级分析，我们演示了总结结局的原理，这些结果总结了1周内的症状经验。这些研究集中在疼痛强度上，该强度用于演示创建摘要瞬时量度的方法。结果：第一项研究（Pain 2008; 139：146-57）的分析得出了基于均值，中位数，第90个百分位数，最大，标准差，无痛报告的比例，疼痛大于50的报告比例的结果指标（以0到100分制为单位）和时变措施。第二项研究在一项纵向研究中检查了这些措施的效果（以及均值），其中一些患者改变了治疗方法（n = 78），从而有可能减轻疼痛，而其他患者则没有改变治疗方法（n = 27）。最好区分这些组的方法是不带疼痛的瞬时报告的比例（效果大小= 0.50），紧随其后的是所有报告的平均值（效果大小= 0.45）。大多数指标还与患者对其变化的总体印象有关（标准差[0.13]除外，介于0.39和0.55之间）。结论：这些分析表明，瞬时症状数据可用于开发反映平均症状以外的症状经验的新PRO。他们强调了从实时研究中收集到的知识，通过展示哪些症状变化与总体感知变化相关，加深了我们对症状的理解。

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