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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Ambulatory monitoring in the genetics of psychosomatic medicine
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Ambulatory monitoring in the genetics of psychosomatic medicine

机译：心身医学遗传学中的动态监控

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摘要

Psychosomatic disorders are composed of an array of psychological, biologic, and environmental features. The existing evidence points to a role for genetic factors in explaining individual differences in the development and maintenance of a variety of disorders, but studies to date have not shown consistent and replicable effects. As such, the attempt to uncover individual differences in the expression of psychosomatic disorders as a function of genetic architecture requires careful attention to their phenotypic architecture or the various intermediate phenotypes that make up a heterogeneous disorder. Ambulatory monitoring offers a novel approach to measuring time-variant and situation-dependent intermediate phenotypes. Recent examples of the use of ambulatory monitoring in genetic studies of stress reactivity, chronic pain, alcohol use disorders, and psychosocial resilience are reviewed in an effort to highlight the benefits of ambulatory monitoring for genetic study designs.
机译：心身疾病由一系列心理，生物学和环境特征组成。现有证据表明，遗传因素在解释各种疾病的发展和维持中的个体差异方面具有作用，但是迄今为止的研究尚未显示出一致且可复制的作用。因此，试图发现心身疾病表达中个体差异作为遗传结构的功能，需要仔细注意它们的表型结构或构成异质性疾病的各种中间表型。动态监控提供了一种新颖的方法来测量时变和情况相关的中间表型。回顾了动态监测在压力反应性，慢性疼痛，饮酒障碍和社会心理适应力的遗传研究中的最新实例，以强调动态监测对遗传研究设计的好处。

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