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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Reaction time as a predictor of mortality: The radiation effects research foundation adult health study
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Reaction time as a predictor of mortality: The radiation effects research foundation adult health study

机译：反应时间可预测死亡率：辐射效应研究基金会成人健康研究

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OBJECTIVE: We investigated the association between reaction time (RT) and mortality in middle-aged and older atomic bomb survivors and their unexposed controls over a period of 30 years. METHODS: During 1970-72, 4912 participants of the Adult Health Study cohort in Hiroshima, Japan, underwent biologic tests including RT. Mortality was followed to the end of 2003. RESULTS: In a multivariate-adjusted model, the hazard ratio (HR) for 1-standard deviation increments of RT was 1.08 (95% confidence interval [CI] = 1.03-1.13) for men, 1.22 (95% CI = 1.16-1.28) for women, and 1.13 (95% CI = 1.09-1.16) for all. When the analysis was performed by sex, age, and follow-up period, a consistent increase of mortality with increments of RT was observed. The HR for mortality for the highest RT quintile was higher than that of the lowest quintile in all sex-age groups. A significant positive association between mortality risk and RT was observed even after 20 years of follow-up (p = .03 in men, p < .001 in women). RT and radiation dose were risk factors for mortality independent of conventional risk factors such as smoking, high blood pressure, and diabetes mellitus. Interaction between RT and radiation dose had no significant effect on mortality in men. Although increased radiation dose reduced the HR for mortality per RT increment in women, RT and radiation dose were still significant predictors of mortality. CONCLUSIONS: RT is a consistently strong predictor of mortality. Although mortality risk increased with radiation dose, radiation did not accelerate the relationship between RT and mortality.
机译：目的：我们调查了中老年原子弹幸存者及其在30年内未受照料的控制者的反应时间（RT）与死亡率之间的关联。方法：在1970-72年间，日本广岛市的成人健康研究队列的4912名参与者接受了包括RT在内的生物学测试。死亡率随访至2003年底。结果：在多变量校正模型中，男性的1标准偏差的风险比（HR）为1.08（95％置信区间[CI] = 1.03-1.13），女性为1.22（95％CI = 1.16-1.28），女性为1.13（95％CI = 1.09-1.16）。当按性别，年龄和随访时间进行分析时，观察到死亡率随RT的增加而持续增加。在所有性别年龄组中，最高RT五分位数的死亡率HR高于最低最低五分位数的死亡率。即使在随访20年后，也观察到死亡率风险与RT之间存在显着的正相关关系（男性p = .03，女性p <.001）。 RT和辐射剂量是死亡率的危险因素，与吸烟，高血压和糖尿病等常规危险因素无关。 RT和辐射剂量之间的相互作用对男性死亡率没有显着影响。尽管增加放射剂量可以降低女性每RT死亡率增加的HR，但是RT和放射剂量仍然是死亡率的重要预测指标。结论：RT一直是死亡率的强有力的预测指标。尽管死亡风险随辐射剂量的增加而增加，但辐射并不能加速RT与死亡率之间的关系。

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