OBJECTIVE: Major depressive disorder (MDD) is common during adolescence, a period characterized by rapid bone mineral accrual. MDD has recently been associated with lower bone mineral density (BMD) in adults. Our objective was to determine whether MDD is associated with BMD, bone turnover markers, vitamin D, and gonadal steroids in adolescents. METHODS: Sixty-five adolescents 12 to 18 years of age (32 boys: 16 with MDD and 16 controls; 33 girls: 17 with MDD and 16 controls) were included in a cross-sectional study. BMD and body composition were obtained by dual-energy x-ray absorptiometry. Estradiol, testosterone, 25-hydroxy vitamin D levels, N-terminal propeptide of Type 1 procollagen (a marker of bone formation), and Type I collagen C-telopeptide (a marker of bone resorption) were measured. RESULTS: Boys with MDD had a significantly lower BMD at the hip (mean [standard deviation] = 0.99 [0.17] g/cm2 versus 1.04 [0.18] g/cm2, body mass index [BMI] adjusted, p = .005) and femoral neck (0.92 [0.17] g/cm2 versus 0.94 [0.17] g/cm2; BMI adjusted, p = .024) compared with healthy controls after adjusting for BMI. This significant finding was maintained after also adjusting for lean mass and bone age (hip: p = .007; femoral neck: p = .020). In girls, there were no significant differences in BMD between the girls with MDD and the controls after adjusting for BMI (p .17). CONCLUSIONS: Male adolescents with MDD have a significantly lower BMD as compared with healthy controls after adjusting for body mass and maturity. This association is not observed in girls.
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机译：目的：重度抑郁症（MDD）常见于青春期，该时期的特征是骨骼矿物质快速积聚。 MDD最近已与成人较低的骨矿物质密度（BMD）相关。我们的目的是确定MDD是否与BMD，骨转换标志物，维生素D和青少年的性腺类固醇有关。方法：一项横断面研究包括了12至18岁的65名青少年（32名男孩：16名患有MDD和16名对照; 33名女孩：17名患有MDD和16名对照）。 BMD和身体组成通过双能X射线吸收法获得。测量了雌二醇，睾丸激素，25-羟基维生素D水平，1型胶原蛋白的N末端前肽（骨形成的标志）和I型胶原蛋白C-端肽（骨吸收的标志）。结果：患有MDD的男孩的髋部BMD显着降低（平均[标准偏差] = 0.99 [0.17] g / cm2对1.04 [0.18] g / cm2，已调整体重指数[BMI]，p = .005）和调整了BMI后与健康对照组相比，股骨颈（0.92 [0.17] g / cm2对0.94 [0.17] g / cm2; BMI进行了调整，p = .024）。在还调整了瘦体重和骨龄后（髋关节：p = .007;股骨颈：p = .020），这一重要发现得以保持。在女孩中，校正了BMI后，患有MDD的女孩与对照组之间的BMD没有显着差异（p> .17）。结论：调整了体重和成熟度后，与健康对照组相比，患有MDD的男性青少年的BMD显着降低。在女孩中没有观察到这种关联。
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