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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Personality and the risk of cancer: A 16-year follow-up study of the GAZEL cohort
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Personality and the risk of cancer: A 16-year follow-up study of the GAZEL cohort

机译：人格与癌症风险：GAZEL研究对象的16年随访研究

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OBJECTIVE: Large-scale prospective studies do not support an association between neuroticism and extroversion with cancer incidence. However, research on other personality constructs is inconclusive. This longitudinal study examined the associations between four personality measures, Type 1, "suppressed emotional expression"; Type 5, "rational/antiemotional"; hostility; and Type A with cancer incidence. METHODS: Personality measures were available for 13,768 members in the GAZEL cohort study (baseline assessment in 1993). Follow-up for diagnoses of primary cancers was obtained from January 1, 1994 to December 31, 2009. Associations between personality and cancer incidence were evaluated using Cox proportional hazards analyses and adjusted for potential confounders. RESULTS: During a median follow-up of 16.0 years (range, 9 days-16 years), 1139 participants were diagnosed as having a primary cancer. The mean duration between baseline and cancer diagnosis was 9.3 years. Type 1 personality was associated with a decreased risk of breast cancer (hazard ratio per standard deviation = 0.81, 95% confidence interval = 0.68-0.97, p = .02). Type 5 personality was not associated with prostate, breast, colorectal, or smoking-related cancers, but was associated with other cancers (hazard ratio per standard deviation = 1.17, 95% confidence interval = 1.04-1.31, p = .01). Hostility was associated with an increased risk of smoking-related cancers, which was explained by smoking habits, and Type A was not associated with any of the cancer endpoints. CONCLUSIONS: Several personality measures were prospectively associated with the incidence of selected cancers. These links may warrant further epidemiological studies and investigations about potential biobehavioral mechanisms.
机译：目的：大规模的前瞻性研究不支持神经质和外向性与癌症发生率之间的关联。但是，关于其他人格建构的研究尚无定论。这项纵向研究检查了四种人格量度（类型1）“抑制的情绪表达”之间的联系。类型5，“理性/反情感”;敌意;和A型癌症的发病率。方法：GAZEL队列研究中有13,768名成员获得了人格测度（1993年的基线评估）。从1994年1月1日至2009年12月31日获得了原发癌诊断的随访资料。使用Cox比例风险分析评估了人格与癌症发病率之间的关联，并针对潜在的混杂因素进行了调整。结果：在16.0年（范围为9天至16年）的中位随访期间，有1139名参与者被诊断患有原发性癌症。从基线到癌症诊断的平均持续时间为9.3年。 1型人格与乳腺癌风险降低相关（每标准偏差的危险比= 0.81，95％置信区间= 0.68-0.97，p = .02）。 5型人格与前列腺癌，乳腺癌，大肠癌或吸烟相关的癌症无关，但与其他癌症相关（每标准差的危险比= 1.17，95％置信区间= 1.04-1.31，p = 0.01）。敌意与吸烟相关的癌症风险增加相关，这由吸烟习惯解释，A型与任何癌症终点均不相关。结论：几种人格测度与某些癌症的发生率相关。这些联系可能需要对潜在的生物行为机制进行进一步的流行病学研究和调查。

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