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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >History of sudden unexpected loss is associated with elevated interleukin-6 and decreased insulin-like growth factor-1 in women in an urban primary care setting.
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History of sudden unexpected loss is associated with elevated interleukin-6 and decreased insulin-like growth factor-1 in women in an urban primary care setting.

机译：在城市初级保健机构中，妇女突然意外损失的病史与白细胞介素6升高和胰岛素样生长因子1降低有关。

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OBJECTIVE: To investigate the hypothesis that a history of sudden unexpected loss including number of losses and type of loss (death due to unnatural versus natural causes) would be associated with the magnitude of dysregulation. The sudden unexpected death of a loved one confers risk of morbidity and mortality, perhaps due to dysregulation in the immune/inflammatory and endocrine systems. METHODS: Female primary care patients aged >or=40 years (n = 75) completed questionnaires, a clinical interview, and a blood draw. Interleukin (IL)-6 and insulin-like growth factor (IGF)-1 were assayed, using standard enzyme-linked immunosorbent assay protocols and anticytokine antibody pairs. RESULTS: History of sudden loss was positively associated with IL-6 (mean = 4.07 pg/mL; log(10) values, B = 0.314, p = .009) and negatively associated with IGF-1 (mean = 97.05 ng/mL; B = -0.277, p = .023). A linear relationship parsimoniously captured the association between ordered categories of lifetime loss (0, 1, 2-5, 5+) and increases in log(10) IL-6 (B = 0.107, p = .005) and decreases in IGF-1 (B = -0.116, p = .005). Adjusting for illness burden, depressive symptom severity, and obesity did not change the observed associations. The hypothesized effect of type of loss was not supported. CONCLUSIONS: These preliminary findings encourage further investigations to elucidate pathways from sudden unexpected loss to biomarker changes that increase risk for morbidity and mortality.
机译：目的：研究以下假设：突然的意外损失的历史（包括损失的数量和损失的类型（因非自然原因或自然原因导致的死亡）与失调的程度有关。亲人突然意外死亡可能会导致发病和死亡的风险，这可能是由于免疫/炎症和内分泌系统失调所致。方法：年龄≥40岁（n = 75）的女性初级保健患者完成问卷调查，临床访谈和抽血。使用标准的酶联免疫吸附试验方案和抗细胞因子抗体对，测定白介素（IL）-6和胰岛素样生长因子（IGF）-1。结果：突然丢失的病史与IL-6呈正相关（平均值= 4.07 pg / mL; log（10）值，B = 0.314，p = .009）与IGF-1呈负相关（平均值= 97.05 ng / mL ; B = -0.277，p = .023）。线性关系简约地捕获了寿命损失的有序类别（0、1、2-5、5 +）与log（10）IL-6的增加（B = 0.107，p = .005）和IGF-的减少之间的关联1（B = -0.116，p = .005）。调整疾病负担，抑郁症状严重程度和肥胖症并没有改变观察到的关联。不支持损失类型的假设效果。结论：这些初步发现鼓励进行进一步的研究，以阐明从突然的意外损失到生物标志物变化的途径，从而增加发病率和死亡率的风险。

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