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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Heart rate and blood pressure changes during autonomic nervous system challenge in panic disorder patients.
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Heart rate and blood pressure changes during autonomic nervous system challenge in panic disorder patients.

机译：恐慌症患者自主神经系统受到挑战期间的心率和血压变化。

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OBJECTIVE: To test the hypothesis that panic disorder (PD) patients have a heightened or deregulated autonomic nervous system at rest and during autonomic challenge compared with healthy controls (HC); and to test a second hypothesis that severity of illness differentiates patients'; sympathovagal balance both at rest and during orthostatic challenge. METHODS: Spectral analysis of heart rate (HR) and blood pressure was performed on 30 PD and 10 HC participants during an orthostatic challenge (head-up tilt). RESULTS: PD patients presented higher HR (p < .001), lower heart rate variability (HRV) (p < .015), higher mean diastolic blood pressure (p < .006), higher low-frequency component of HR (p < .001), and a higher ratio of low-frequency to high-frequency component of HR (LF/HF) (p < .022) than HC at baseline. During tilt, PD patients responded with higher HR (p < .039), lower HRV (p < .043), increased mean diastolic blood pressure (p < .028), and a mild increase in LF/HF, whereas controls responded with a five-fold increase in LF/HF (p < .022). Patients with higher illness severity ratings (Clinical Global Impression Scale) showed higher HR (p < .002), lower HRV (p < .026), and a lower total power of systolic blood pressure (p < .02) compared with less ill patients. CONCLUSION: These findings demonstrate a consistently higher or deregulated autonomic arousal in PD patients at rest and during orthostatic challenge compared with HC. These data also reveal a possible association between the level of anxiety illness severity and sympathovagal balance, which may imply greater cardiac risk.
机译：目的：检验以下假设：与健康对照组（HC）相比，恐慌症（PD）患者在休息和自主神经攻击期间自主神经系统增高或失调;并检验第二种假说，即疾病的严重程度可以区分患者的病情;静止和体位挑战过程中交感神经平衡。方法：在体位性挑战（抬头倾斜）期间，对30名PD和10名HC参与者进行了心率（HR）和血压的频谱分析。结果：PD患者表现出较高的HR（p <.001），较低的心率变异性（HRV）（p <.015），较高的平均舒张压（p <.006），较高的HR低频成分（p < .001），并且在基线时HR的低频分量与高频分量之比（LF / HF）较高（p <.022）。在倾斜过程中，PD患者的HR较高（p <.039），HRV较低（p <.043），平均舒张压升高（p <.028），LF / HF轻度升高，而对照组则以LF / HF增加了五倍（p <.022）。疾病严重程度等级较高（临床总体印象量表）的患者与较少患病的患者相比，具有更高的HR（p <.002），更低的HRV（p <.026）和更低的总收缩压（p <.02）耐心。结论：这些发现表明，与HC相比，PD患者在休息和体位挑战期间的自主神经唤醒持续升高或失调。这些数据还揭示出焦虑症严重程度与交感神经平衡之间可能存在关联，这可能意味着更高的心脏风险。

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