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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Classical conditioning of insulin effects in healthy humans.
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Classical conditioning of insulin effects in healthy humans.

机译：在健康人类中胰岛素作用的经典调节。

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OBJECTIVE: Classical conditioning of insulin effects was examined in healthy humans using a placebo-controlled design. This study examined whether subjects who experienced a conditioned stimulus (CS) paired with insulin in the acquisition phase of a conditioning protocol would show a conditioned decrease of blood glucose when receiving the CS with a placebo injection in the test phase. METHODS: Twenty healthy male students were assigned either to group 1, which received insulin (0.035 IU/kg i.v.), or to group 2, which received i.v. saline on 4 consecutive days (acquisition). On day 5 (test), both groups were injected with saline. The CS was an olfactory stimulus. Blood glucose, serum insulin, plasma glucagon, plasma catecholamines, serum cortisol, and symptoms were repeatedly measured during each session. RESULTS: In the test phase, group 1 reacted with a significantly larger decrease of blood glucose after presentation of the CS than group 2. Within group 1, a larger conditioned blood glucose decrease was associated with features that enhance classical conditioning (ie, intensity of the unconditioned response and intensity of the CS). Furthermore, in group 1, there was an increase of baseline insulin from day 1 to day 5 and a tendency for insulin reduction after CS presentation. Groups also tended to differ in cortisol and neuroglycopenic symptoms after CS presentation. CONCLUSIONS: Conditioned effects in blood glucose are in accordance with the predictions. As a result of the exploratory analyses, our data also provide hints about conditioned changes in insulin, counterregulatory hormones, and symptoms.
机译：目的：使用安慰剂对照设计在健康人群中检查经典的胰岛素作用条件。这项研究检查了在调节方案的获取阶段经历过与胰岛素配对的条件刺激（CS）的受试者在测试阶段通过安慰剂注射接受CS时是否会显示出血糖的条件降低。方法：将20名健康的男学生分配到接受胰岛素（0.035 IU / kg静脉注射）的第1组或接受静脉注射胰岛素的第2组。连续4天（获取）添加生理盐水。在第5天（测试），两组均注射盐水。 CS是一种嗅觉刺激。在每个疗程中重复测量血糖，血清胰岛素，血浆胰高血糖素，血浆儿茶酚胺，血清皮质醇和症状。结果：在测试阶段，出现CS后，第1组的血糖下降明显大于第2组。在第1组中，较大的调节后血糖下降与增强经典调节的功能（即，强度增加）有关。 CS的无条件响应和强度）。此外，在第1组中，从第1天到第5天，基线胰岛素增加，并且在出现CS后出现胰岛素减少的趋势。 CS表现后，各组的皮质醇和神经血糖症状也趋于不同。结论：血糖的条件作用与预测一致。作为探索性分析的结果，我们的数据还提供了有关胰岛素，反调节激素和症状的条件性变化的暗示。

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