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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Ecological momentary assessment of maternal cortisol profiles over a multiple-day period predicts the length of human gestation.
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Ecological momentary assessment of maternal cortisol profiles over a multiple-day period predicts the length of human gestation.

机译：对孕妇皮质醇在多天时间内进行的生态瞬时评估可预测人类妊娠的时间。

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OBJECTIVE: Biobehavioral models of prenatal stress highlight the importance of the stress-related hormone cortisol. However, the association between maternal cortisol levels and the length of human gestation requires further investigation because most previous studies have relied on one-time cortisol measures assessed at varying gestational ages. This study assessed whether ecological momentary assessment (EMA) of cortisol sampling improves the ability to predict the length of human gestation. In addition, associations between EMA-based measures of psychological state (negative affect) with cortisol levels during pregnancy were assessed. METHODS: For a 4-day period, 25 healthy pregnant women (mean gestational age at assessment = 23.4 [standard deviation = 9.1] weeks) collected seven salivary samples per day for the assessment of cortisol and provided a rating of negative affect every waking hour using an electronic diary. RESULTS: Higher salivary cortisol concentrations at awakening and throughout the day (p = .001), as well as a flatter cortisol response to awakening (p = .005), were associated with shorter length of gestation. Women who delivered an infant at 36 weeks of gestations had 13% higher salivary cortisol levels at awakening than women who delivered an infant at 41 weeks of gestation. The EMA-based measure of negative affect was associated with higher cortisol throughout the day (p = .006) but not to gestational length (p = .641). The one-time measure of cortisol was not associated with length of gestation, and traditional retrospective recall measures of negative affect were not associated with cortisol. CONCLUSIONS: Our findings support the ecological validity of repeated ambulatory assessments of cortisol in pregnancy and their ability to improve the prediction of adverse birth outcomes.
机译：目的：产前应激的生物行为模型凸显了应激相关激素皮质醇的重要性。然而，由于大多数先前的研究都依赖于在不同胎龄下评估的一次性皮质醇测量值，因此母亲皮质醇水平与人类妊娠时间之间的关联需要进一步研究。这项研究评估了皮质醇采样的生态瞬时评估（EMA）是否提高了预测人类妊娠长度的能力。此外，评估了基于EMA的心理状态（负面影响）量度与妊娠期间皮质醇水平之间的关联。方法：在为期4天的研究中，每天有25名健康孕妇（评估时的平均胎龄= 23.4 [标准差= 9.1]周）收集了七个唾液样本用于评估皮质醇，并在每个醒来时提供了负面影响评估使用电子日记。结果：觉醒时和全天唾液皮质醇浓度较高（p = .001），而皮质醇对觉醒的反应较平坦（p = .005），与妊娠时间短有关。在妊娠36周时分娩的妇女比在妊娠41周时分娩的妇女清醒时唾液皮质醇水平高13％。基于EMA的负面影响量度与全天较高的皮质醇（p = .006）相关，但与妊娠期无关（p = .641）。皮质醇的一次性测量与妊娠时间无关，传统的负面影响的回顾性召回措施与皮质醇无关。结论：我们的研究结果支持对妊娠期间皮质醇进行反复动态评估的生态学有效性，以及其改善不良分娩预后的能力。

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