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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Stress reduces diastolic function in youth
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Stress reduces diastolic function in youth

机译：压力会降低年轻人的舒张功能

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Objective: Research regarding the influence of mental stress (MS) on heart function focused primarily on heart contractility. We hypothesized that MS results in attenuated diastolic function (DF) as early as in adolescence and this effect may differ by race and sex. Methods: 161 normotensive adolescents (81 blacks and 80 females) performed resting (control) and MS (experimental) conditions on separate visits. Visits lasted for 3 hours (1-hour rest, video game challenge and recovery for experimental visit. Mitral inflow early (E) to late (A) filling velocities (E/A) ratio; mitral valve annular early velocity (E′) and E/E′ ratio were recorded every 30 minutes to evaluate DF. Results: BP and HR increased during experimental visit (all p values < .01). E/A ratio progressively increased during control visit (mean [SE], from 1.93 ± 0.42 to 2.01 ± 0.47) but decreased during the stress phase of experimental visit (from 1.91 ± 0.44 to 1.87 ± 0.50, p interaction < .001). In white males, E′ increased from rest to stress phase (from 10.3 ± 2.55 to 10.7 ± 2.28 cm/s), whereas E′ decreased in white females (from 11.0 ± 2.62 to 10.6 ± 2.53 cm/s), black males (from 10.5 ± 2.31 to 9.9 ± 2.19 cm/s), and black females (from 10.6 ± 2.22 to 10.3 ± 1.86 cm/s, p interaction < .04). During stress, higher A was associated with higher E/E′ ratio. Conclusions: Recurrent episodes of mental stress may increase the risk of poor DF, and these adverse effects may be stronger in females and black males.
机译：目的：关于精神压力（MS）对心脏功能的影响的研究主要集中在心脏收缩性上。我们假设MS早在青春期就会导致舒张功能减弱（DF），并且这种影响可能因种族和性别而异。方法：161名血压正常的青少年（81名黑人和80名女性）在单独的探访中进行了休息（对照）和MS（实验）条件。访视持续3小时（休息1小时，进行视频游戏挑战并进行实验性访视恢复。二尖瓣早期流入（E）到晚期（A）填充速度（E / A）比率;二尖瓣环早期流速（E'）和每30分钟记录一次E / E'比，以评估DF结果：实验访问期间BP和HR升高（所有p值<.01）。对照访问期间E / A比逐渐升高（平均值[SE]从1.93± 0.42至2.01±0.47），但在实验拜访的压力阶段下降（从1.91±0.44到1.87±0.50，p相互作用<.001）。在白人男性中，E'从静止状态增加到压力阶段（从10.3±2.55至白人女性（从11.0±2.62到10.6±2.53 cm / s），黑人男性（从10.5±2.31到9.9±2.19 cm / s），E'下降，而黑人女性（从10.6±2.22至10.3±1.86 cm / s，p交互作用<.04）。在压力下，较高的A与较高的E / E'比相关。结论：精神压力的反复发作可能会增加风险DF不良，女性和黑人男性的不良反应可能更严重。

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