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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Serotonergic and BDNF genes associated with depression 1 week and 1 year after mastectomy for breast cancer.
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Serotonergic and BDNF genes associated with depression 1 week and 1 year after mastectomy for breast cancer.

机译：乳腺癌切除术后1周和1年，血清素能和BDNF基因与抑郁症相关。

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OBJECTIVE: Polymorphisms of serotonin transporter (5-HTT) and brain-derived neurotrophic factor (BDNF) genes have been investigated as candidate genes for depression occurring in medical disorders. The serotonin 2a receptor (5-HTR2a) genes have been investigated as risk factors for depression but rarely in combination with medical conditions. This study aimed to investigate whether polymorphisms of interest in 5-HTT, 5-HTR2a, and BDNF genes are associated with depression after mastectomy for breast cancer. METHODS: A total of 309 patients with breast cancer were evaluated 1 week after mastectomy, and 244 patients (79%) were followed up 1 year later. Depression (major and minor depressive disorders) was diagnosed according to DSM-IV criteria using the Mini-International Neuropsychiatric Interview and was classified into prevalent, persistent, and incident depression. Individual associations with 5-HTT gene-linked promoter region, serotonin transporter intron 2 variable number tandem repeat, 5-HTR2a 1438A/G, 5-HTR2a 102T/C, and BDNF Val66Met polymorphisms were estimated using logistic regression models, and gene-gene interactions were investigated using the generalized multifactor dimensionality reduction method. RESULTS: At baseline, 74 patients (24%) were classified with prevalent depression, and at follow-up, 19 patients (8%) and 25 patients (10%) were classified with persistent and incident depression, respectively. The BDNF Met/Met genotype was independently associated with prevalent (odds ratio = 2.63, 95% confidence interval = 1.12-6.14) and persistent (odds ratio = 8.07, 95% confidence interval = 1.26-51.6) depression. No associations with 5-HTT and 5-HTR2a genes (all p values > .21) were found, and no significant gene-gene interactions were identified (all p values > .36). CONCLUSIONS: Our findings support a role of BDNF, not serotonin, in the etiology of depression occurring in women with breast cancer who received a mastectomy.
机译：目的：研究5-羟色胺转运蛋白（5-HTT）和脑源性神经营养因子（BDNF）基因的多态性，作为医学疾病中抑郁症的候选基因。已研究了血清素2a受体（5-HTR2a）基因作为抑郁的危险因素，但很少与医学状况相结合。这项研究的目的是调查乳腺癌切除术后5-HTT，5-HTR2a和BDNF基因感兴趣的多态性是否与抑郁症相关。方法：对乳房切除术后1周的309例乳腺癌患者进行了评估，并在1年后对244例患者（79％）进行了随访。抑郁症（重度和轻度抑郁症）是根据《 Mini-International Neuropsychiatric Interview》根据DSM-IV标准诊断的，分为普遍性，持续性和突发性抑郁症。使用逻辑回归模型和基因基因估计与5-HTT基因连锁的启动子区域，5-羟色胺转运蛋白内含子2可变数目串联重复序列，5-HTR2a 1438A / G，5-HTR2a 102T / C和BDNF Val66Met多态性的个体关联。使用广义多因素降维方法研究了相互作用。结果：在基线时，将74例患者（24％）归为普遍抑郁症，在随访中，分别将19例患者（8％）和25例患者（10％）归为持续性抑郁和突发性抑郁。 BDNF Met / Met基因型与普遍的抑郁（赔率= 2.63，95％置信区间= 1.12-6.14）和持续性（赔率= 8.07，95％置信区间= 1.26-51.6）相关。没有发现与5-HTT和5-HTR2a基因的关联（所有p值> 0.21），也没有发现显着的基因-基因相互作用（所有p值> 0.36）。结论：我们的发现支持BDNF而不是5-羟色胺在接受乳房切除术的乳腺癌妇女发生抑郁的病因中的作用。

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