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How many meta-analyses does it take to settle a question?

机译:解决一个问题需要进行多少次荟萃分析?

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Psychological treatments (PTs) are used as adjuncts to cardiac care. This issue of Psychosomatic Medicine provides a meta-analysis by Rutledge et al. () on the effects of PT and cardiac rehabilitation on depression and cardiac outcomes, and the journal recently published a systematic review and meta-regression on a similar topic by Dickens et al. (). This editorial compares the results from these two meta-analyses and discusses the problems associated with combining different types of PT and other treatments, dose-response effects, floor effects, collapsing across outcomes, and therapist qualifications. PTs have mixed but generally positive effects on reducing mortality and cardiac outcomes, but it remains a challenge explaining how such beneficial outcomes can be achieved by relatively small effects on well-being (typical effect sizes: d = 0.2-0.3). Randomized controlled trials are needed on timing of PT, patients with cardiac problems who will benefit most from PT, and the mechanisms by which PT improves cardiac outcomes.
机译:心理治疗(PT)被用作心脏护理的辅助手段。本期《心身医学》提供了Rutledge等人的荟萃分析。 ()关于PT和心脏康复对抑郁症和心脏预后的影响,该期刊最近发表了Dickens等人对类似主题的系统评价和meta回归。 ()。这篇社论比较了这两项荟萃分析的结果,并讨论了将不同类型的PT与其他治疗方法结合使用,剂量反应效果,场效应,结局崩溃和治疗师资格相关的问题。 PT在降低死亡率和心脏结局方面具有不同但总体上积极的作用,但仍然难以解释如何通过对幸福感的相对较小的影响来实现这种有益的结果(典型的影响大小:d = 0.2-0.3)。需要进行PT时机,心脏疾病患者将从PT中获益最多的随机对照试验,以及PT改善心脏结局的机制。

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