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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Effect of paroxetine on physiological response to stress and smoking
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Effect of paroxetine on physiological response to stress and smoking

机译：帕罗西汀对应激和吸烟的生理反应的影响

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OBJECTIVE: Smokers often smoke during stressful events, which leads to large increases in cardiovascular measures such as blood pressure (BP) and heart rate (HR). Because exaggerated cardiovascular response to stress is associated with cardiovascular disease risk, this study examined paroxetine's effect on the physiological response to combining stress and smoking. METHODS: Sixty-two participants completed this randomized, double-blind, crossover study in which BP, HR, plasma epinephrine, norepinephrine, and cortisol concentrations were measured at rest, while smoking, and during a speech and math task. Laboratory sessions occurred after 1 month of paroxetine and after 1 month of placebo. RESULTS: Significant increases occurred for all measures (except cortisol) during smoking, with further increases occurring during the speech task (time effect, p < .001). After 1 month of paroxetine, norepinephrine and HR values were lower and cortisol values were higher (versus placebo) throughout the laboratory session (treatment effect, p < .001). Treatment × time effects were observed for BP and HR (all, p < .01). For systolic and diastolic BP, a smaller increase (from baseline to measures during speech) was observed after paroxetine compared with placebo (both, p < .006). In both measures, the increase in response to smoking was similar for both treatments; however, the further increase during the speech was smaller when taking paroxetine (versus placebo). CONCLUSIONS: This study suggests that paroxetine affects physiological response to stress in smokers. Further research is needed to determine the impact of these results on cardiovascular health.
机译：目的：吸烟者经常在压力事件中吸烟，这导致心血管指标（例如血压（BP）和心率（HR））大大增加。由于夸张的对压力的心血管反应与心血管疾病的风险有关，因此本研究研究了帕罗西汀对压力和吸烟相结合的生理反应的影响。方法：62名参与者完成了这项随机，双盲，交叉研究，该研究在休息，吸烟，演讲和数学任务期间测量血压，心率，血浆肾上腺素，去甲肾上腺素和皮质醇的浓度。帕罗西汀1个月后和安慰剂1个月后进行实验室检查。结果：吸烟期间所有措施（皮质醇除外）均显着增加，而语音任务期间则进一步增加（时间效应，p <.001）。帕罗西汀治疗1个月后，在整个实验室期间，去甲肾上腺素和HR值较低，皮质醇值较高（与安慰剂相比）（治疗效果，p <0.001）。观察到BP和HR的治疗×时间效应（所有，p <.01）。对于收缩压和舒张压，与安慰剂相比，帕罗西汀治疗后观察到较小的增加（从基线到言语期间的测量）（两者，p <.006）。在这两种方法中，两种治疗方法对吸烟的反应均相似。然而，在演讲期间，服用帕罗西汀（与安慰剂相比）的进一步增加较小。结论：这项研究表明帕罗西汀影响吸烟者对压力的生理反应。需要进一步的研究以确定这些结果对心血管健康的影响。

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