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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >The relationship between depressive symptoms and restless legs syndrome in two prospective cohort studies
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The relationship between depressive symptoms and restless legs syndrome in two prospective cohort studies

机译：两项前瞻性队列研究中抑郁症状与不安腿综合征之间的关系

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OBJECTIVE: Cross-sectional studies suggest a strong association between depression and restless legs syndrome (RLS); however, the temporal relationship between the two disorders remains unknown. We tested whether the presence of clinically relevant depressive symptoms (CRDS) is a risk factor for subsequent RLS in the general population. The relationship between prevalent RLS and incident CRDS was also examined. METHODS: Two independent, prospective cohort studies with representative, age-stratified random samples, the Dortmund Health Study (DHS; n = 1312/1122 [baseline/follow-up], median follow-up time = 2.1 years) and the Study of Health in Pomerania (SHIP; n = 4308/3300, median follow-up time = 5.0 years) were analyzed. RLS was assessed in both studies according to the RLS minimal criteria, at baseline and at follow-up. CRDS were assessed by the Center for Epidemiologic Studies-Depression scale (a score of ≥16) in DHS only at baseline and by the Munich-Composite International Diagnostic-Screener in SHIP at baseline and at follow-up. RESULTS: Clinically relevant depressive symptoms at baseline were associated new-onset RLS in both studies (DHS: odds ratio [OR] = 1.94, 95% confidence interval [CI] = 1.09-3.44; SHIP: OR = 2.37, 95% CI = 1.65-3.40) after adjustment for age, sex, education, body mass index, smoking, physical activity, and the presence of various comorbidities. RLS at baseline was an independent risk factor of incident CRDS in SHIP (OR = 1.82, 95% CI = 1.10-3.00). CONCLUSIONS: The presence of CRDS may be a risk factor for subsequent RLS. The relationship between the two disorders might be bidirectional because RLS also predicts incident depressive symptoms.
机译：目的：横断面研究表明抑郁症与腿不安定综合征（RLS）之间存在很强的相关性。然而，这两种疾病之间的时间关系仍然未知。我们测试了临床相关的抑郁症状（CRDS）的存在是否是普通人群随后发生RLS的危险因素。还检查了流行的RLS和事件CRDS之间的关系。方法：两项独立的，具有代表性的，按年龄分层的随机样本的前瞻性队列研究，多特蒙德健康研究（DHS; n = 1312/1122 [基线/随访]，中位随访时间= 2.1年）和分析了Pomerania的健康状况（SHIP; n = 4308/3300，中位随访时间= 5.0年）。两项研究均在基线和随访时根据RLS最低标准评估了RLS。仅在基线时，由DHS的流行病学研究中心-抑郁量表（≥16评分）评估CRDS，在基线及后续时，由SHIP的Munich-Composite International Diagnostic-Screener评估。结果：在两项研究中，基线时临床相关的抑郁症状与新发的RLS相关（DHS：优势比[OR] = 1.94，95％置信区间[CI] = 1.09-3.44; SHIP：OR = 2.37，95％CI =调整年龄，性别，教育程度，体重指数，吸烟，体力活动和各种合并症的情况后（1.65-3.40）。基线时的RLS是SHIP中发生CRDS的独立危险因素（OR = 1.82，95％CI = 1.10-3.00）。结论：CRDS的存在可能是随后RLS的危险因素。两种疾病之间的关系可能是双向的，因为RLS还可以预测抑郁症状。

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